Soy phytoestrogen supplementation and menopause

大豆植物雌激素补充和更年期

• 批准号: 7228990
• 负责人: CYNTHIA K SITES
• 金额: $ 13.29万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7228990
• 关键词: Asia; Award; Body Composition; Cardiovascular Diseases; Clinical Investigator; Clinical Research; Daily; Data; Diabetes Mellitus; Diet; Dietary Supplementation; Discipline of obstetrics; Ensure; Estrogen Replacements; Estrogens; Fellowship Program; Glucose; Goals; Gynecology; Hormone replacement therapy; Human; Incidence; Infertility; Insulin; Insulin Resistance; Knowledge; Longitudinal Studies; Medical Students; Medicine; Menopausal Symptom; Menopause; Mentors; Metabolic; Metabolism; Mid-Career Clinical Scientist Award (K24); Obesity; Operative Surgical Procedures; Ovarian; Ovarian hormone; Physiological; Phytoestrogens; Postmenopause; Production; Progestins; Publications; Randomized Controlled Trials; Reporting; Reproductive Endocrinology; Research; Research Project Grants; Risk; Rodent; Site; Soy Proteins; Supplementation; Training; Universities; Vermont; Woman; Women' s Health; age related; cardiovascular disorder risk; cardiovascular risk factor; college; diabetes risk; glucose disposal; glucose metabolism; improved; insulin secretion; insulin sensitivity; interest; non-diabetic; novel therapeutics; patient oriented research; professor; soy; soy protein isolate

DESCRIPTION (provided by applicant): Dr. Cynthia K. Sites is an Associate Professor of Obstetrics and Gynecology and Director of the Fellowship Program in Reproductive Endocrinology and Infertility at the University of Vermont College of Medicine. Dr. Sites' major research goal is to understand and develop new therapeutic strategies to alleviate increased cardiovascular disease risk following menopause. This K24 Midcareer Award in Patient-Oriented Research will ensure that Dr. Sites devotes at least 40% of her effort to patient-oriented research and mentoring of clinical investigators. Although Dr. Sites has conducted several patient-oriented research projects toward this goal, this proposal describes Dr. Sites' study, "Soy Phytoestrogens and Metabolic Cardiovascular Risk." Since the publication of the Women's Health Initiative findings, postmenopausal women are discontinuing hormone replacement therapy and considering alternative strategies such as soy phytoestrogens. Our overall hypothesis is that dietary supplementation with soy phytoestrogens improves glucose metabolism by increasing glucose disposal and reducing insulin secretion, which reduce the risk of cardiovascular disease. Fellows to be mentored by Dr. Sites through this K24 award will be trained to develop hypotheses and carry out projects consistent with these goals. The Candidate has demonstrated continued commitment to mentoring and training fellows, residents, and medical students in Patient-Oriented Research, and has the full support of her department and the General Clinical Research Center for this project.

描述（由申请人提供）：Dr. Cynthia K. Sites是佛蒙特大学医学院妇产科副教授，生殖内分泌学和不孕症奖学金项目主任。Sites博士的主要研究目标是了解和开发新的治疗策略，以减轻绝经后心血管疾病风险的增加。这个K24以患者为导向的研究中期奖将确保博士网站投入至少40%的努力，以患者为导向的研究和指导临床研究者。尽管Sites博士已经进行了几个以患者为导向的研究项目，但本提案描述了Sites博士的研究“大豆植物雌激素和代谢性心血管风险”。“自从妇女健康倡议的研究结果发表以来，绝经后妇女正在停止激素替代疗法，并考虑替代策略，如大豆植物雌激素。我们的总体假设是，膳食补充大豆植物雌激素通过增加葡萄糖处置和减少胰岛素分泌来改善葡萄糖代谢，从而降低心血管疾病的风险。通过K24奖项，由Dr. Sites指导的研究员将接受培训，以制定假设并开展与这些目标一致的项目。 候选人已经证明了继续致力于指导和培训研究员，居民和医学生以患者为导向的研究，并得到了她的部门和一般临床研究中心对该项目的全力支持。