SOY AND METABOLISM IN MENOPAUSE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 基本原理：绝经与胰岛素抵抗增加有关。雌激素替代可改善胰岛素抵抗。自妇女健康倡议的调查结果发表以来，妇女正在停止激素替代疗法，并开始替代疗法，如大豆植物雌激素，尽管其预防疾病的功效证据有限。 假设：我们的总体假设是，饮食中补充大豆植物雌激素通过增加葡萄糖处置和减少肥胖绝经后妇女的胰岛素分泌来改善葡萄糖代谢，而与身体成分的变化无关。 实验方法：共招募70名女性进行为期3个月的随机、双盲、安慰剂对照研究。女性将被随机分配至：1）复兴大豆奶昔（16克大豆蛋白和120 mg大豆酮），或2）安慰剂（酪蛋白）奶昔，每日一次。在基线和3个月时，我们将使用高血糖钳夹方法测量葡萄糖处置和胰岛素分泌，并使用计算机断层扫描和双能X射线吸收光谱法测量身体组成。 重要性：本研究将提供大豆植物雌激素补充剂对肥胖绝经后妇女糖代谢影响的新知识，这将对临床护理产生影响。此外，我们的研究结果将为大豆植物雌激素补充剂和人类葡萄糖代谢的生理机制提供新的知识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rationale: Menopause has been associated with increased insulin resistance. Estrogen replacement may improve insulin resistance. Since the publication of the Women's Health Initiative findings, women are discontinuing hormone replacement therapy and starting alternative treatments such as soy phytoestrogens, despite limited evidence for their efficacy in disease prevention. Hypothesis: Our overall hypothesis is that dietary supplementation with soy phytoestrogens improves glucose metabolism by increasing glucose disposal and reducing insulin secretion in obese postmenopausal women, independently of changes in body composition. Experimental approach: A Total of 70 women will be recruited for the 3-month randomized, doubleblinded, placebo-controlled study. Women will be randomized to: 1) Revival Soy shakes(l6 grams of soy protein and 120 mg isoflavones), or 2) placebo (casein) shakes daily. At baseline and 3 months, we will measure glucose disposal and insulin secretion using hypaglycemic clamp methodology, and body composition using computer tomography and dual energy x-ray absorptiornetry. Significance: This study will provide new knowledge on the effects of soy phytoestrogen supplementation on glucose metabolism in obese postmenopausal women which will impact on clinical care. In addition, our findings will provide new knowledge of physiologic mechanisms involved with soy phytoestrogen supplementation and glucose metabolism in humans.