SOY AND METABOLISM IN MENOPAUSE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rationale: Menopause has been associated with increased insulin resistance. Estrogen replacement may improve insulin resistance. Since the publication of the Women's Health Initiative findings, women are discontinuing hormone replacement therapy and starting alternative treatments such as soy phytoestrogens, despite limited evidence for their efficacy in disease prevention. Hypothesis: Our overall hypothesis is that dietary supplementation with soy phytoestrogens improves glucose metabolism by increasing glucose disposal and reducing insulin secretion in obese postmenopausal women, independently of changes in body composition. Experimental approach: A Total of 70 women will be recruited for the 3-month randomized, doubleblinded, placebo-controlled study. Women will be randomized to: 1) Revival Soy shakes(l6 grams of soy protein and 120 mg isoflavones), or 2) placebo (casein) shakes daily. At baseline and 3 months, we will measure glucose disposal and insulin secretion using hypaglycemic clamp methodology, and body composition using computer tomography and dual energy x-ray absorptiornetry. Significance: This study will provide new knowledge on the effects of soy phytoestrogen supplementation on glucose metabolism in obese postmenopausal women which will impact on clinical care. In addition, our findings will provide new knowledge of physiologic mechanisms involved with soy phytoestrogen supplementation and glucose metabolism in humans.