Studies in Children with Digestive Disorders

儿科疾病的临床研究对于确保有这些问题的婴儿、儿童和青少年的管理、预后和生活质量的进步至关重要。目标是(1)在假设驱动的儿科胃肠病学和营养学的专家临床研究中促进一个项目，(2)在儿科胃肠病学和营养学研究方面指导年轻的临床医生，以及(3)促进与临床研究人员的持续互动和合作。为了实现这些目标，在海曼博士和他的合作者的指导和监督下，各级受训人员将进行目前的项目和未来对儿科患者胃肠道和营养问题的调查。涉及炎症性肠病(克罗恩病和溃疡性结肠炎)、艾滋病毒感染、家族性腺瘤性息肉综合征(带有FAP基因突变)、营养不良的鱼鳞病和胃食道反流病的儿科患者的研究目前正在进行中或计划利用加州大学旧金山分校(UCSF)儿科胃肠/营养诊所和儿科临床研究中心的设施和工作人员进行。一项队列研究正在规划阶段，以确定营养建议是否有助于改善饮食行为和健康状况的长期结果(例如，微量营养素充分性；以及生长参数)。这项建议的首要目标是激励和激励年轻的临床医生从事专注于临床研究的职业。将指导儿科胃肠病实习生在婴儿、儿童和青少年中正确地进行前瞻性随机对照临床试验。受训人员还将参加教学课程，涵盖临床试验设计和程序、方案编写、数据管理和伦理考虑。这一奖项将增强申请者将更多时间投入与研究有关的活动的能力，并为学员迈向富有成效的科学职业提供指导和指导。

Clinical research in pediatric disorders is essential to ensure advances in the management, prognosis and quality of life of infants, children and adolescents with these problems. The goals are (1) to foster a program in hypothesis-driven, expert clinical research in pediatric gastroenterology and nutrition, (2) to mentor young clinicians in pediatric gastroenterology and nutrition research, and (3) to promote ongoing interactions and collaborations with clinical investigators. To achieve these goals, current projects and future investigations of gastrointestinal and nutrition problems in pediatric patients will be conducted by trainees at various levels under the guidance and supervision of Dr. Heyman and his collaborators. Studies involving pediatric patients with inflammatory bowel disease (Crohn's disease and ulcerative colitis), HIV infection, familial adenomatous polyposis syndrome (with FAP gene mutations), ichthyosis erythrodermas with poor nutrition, and gastroesophageal reflux disease are currently ongoing or planned utilizing the facilities and staffs of the Pediatric Gastroenterology/Nutrition Clinics and the Pediatric Clinical Research Center at the University of California, San Francisco (UCSF). A cohort study is in the planning stage to determine whether nutrition advice promotes improved long-term outcomes in eating behaviors and health status (e.g., micronutrient adequacy; and growth parameters). The overriding objective of this proposal is to motivate and inspire young clinicians embarking on careers focused on clinically oriented research. Pediatric gastroenterology trainees will be instructed in the proper conduct of perspective randomized controlled clinical trials in infants, children, and adolescents. Trainees will also participate in didactic courses covering clinical trial design and procedure, protocol writing, data management, and ethical considerations. This award will enhance the applicant's ability to devote more time to research- related activities, and to provide guidance and instruction for trainees advancing towards productive scientific careers.