Studies in Children with Digestive Disorders

消化系统疾病儿童的研究

• 批准号: 6777065
• 负责人: MELVIN B. HEYMAN
• 金额: $ 12.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6777065
• 关键词: Crohn' s disease; children; diet therapy; digestive disorder; human subject; human therapy evaluation; nutrition disorders; nutrition related tag; patient oriented research; pediatrics; reflux esophagitis; ulcerative colitis

Clinical research in pediatric disorders is essential to ensure advances in the management, prognosis and quality of life of infants, children and adolescents with these problems. The goals are (1) to foster a program in hypothesis-driven, expert clinical research in pediatric gastroenterology and nutrition, (2) to mentor young clinicians in pediatric gastroenterology and nutrition research, and (3) to promote ongoing interactions and collaborations with clinical investigators. To achieve these goals, current projects and future investigations of gastrointestinal and nutrition problems in pediatric patients will be conducted by trainees at various levels under the guidance and supervision of Dr. Heyman and his collaborators. Studies involving pediatric patients with inflammatory bowel disease (Crohn's disease and ulcerative colitis), HIV infection, familial adenomatous polyposis syndrome (with FAP gene mutations), ichthyosis erythrodermas with poor nutrition, and gastroesophageal reflux disease are currently ongoing or planned utilizing the facilities and staffs of the Pediatric Gastroenterology/Nutrition Clinics and the Pediatric Clinical Research Center at the University of California, San Francisco (UCSF). A cohort study is in the planning stage to determine whether nutrition advice promotes improved long-term outcomes in eating behaviors and health status (e.g., micronutrient adequacy; and growth parameters). The overriding objective of this proposal is to motivate and inspire young clinicians embarking on careers focused on clinically oriented research. Pediatric gastroenterology trainees will be instructed in the proper conduct of perspective randomized controlled clinical trials in infants, children, and adolescents. Trainees will also participate in didactic courses covering clinical trial design and procedure, protocol writing, data management, and ethical considerations. This award will enhance the applicant's ability to devote more time to research- related activities, and to provide guidance and instruction for trainees advancing towards productive scientific careers.

儿科疾病的临床研究对于确保有这些问题的婴儿、儿童和青少年在管理、预后和生活质量方面取得进展至关重要。目标是(1)培养一个假设驱动的儿科胃肠病学和营养学专家临床研究项目，(2)指导儿科胃肠病学和营养学研究的年轻临床医生，(3)促进与临床研究者的持续互动和合作。为了实现这些目标，在Heyman博士及其合作者的指导和监督下，目前的项目和未来对儿科患者胃肠道和营养问题的调查将由不同层次的学员进行。涉及炎性肠病（克罗恩病和溃疡性结肠炎）、HIV感染、家族性腺瘤性息肉病综合征（伴有FAP基因突变）、营养不良的红皮鱼鳞病和胃食管反流病的儿科患者的研究目前正在进行或计划利用儿科胃肠病学/营养诊所和加州大学旧金山分校（UCSF）儿科临床研究中心的设施和工作人员。一项队列研究正处于规划阶段，以确定营养建议是否能促进改善饮食行为和健康状况的长期结果（例如微量营养素充足性和生长参数）。该提案的首要目标是激励和激励年轻临床医生从事临床导向研究的职业。儿科胃肠病学学员将被指导在婴儿、儿童和青少年中正确进行前瞻性随机对照临床试验。受训者还将参加包括临床试验设计和程序、方案编写、数据管理和伦理考虑在内的教学课程。该奖项将增强申请人投入更多时间于研究相关活动的能力，并为学员迈向富有成效的科学事业提供指导和指导。