Studies in Children with Digestive Disorders

消化系统疾病儿童的研究

• 批准号: 8094241
• 负责人: MELVIN B. HEYMAN
• 金额: $ 17.69万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8094241
• 关键词: Acculturation; Adult; Age-Years; Area; Basic Science; Biography; California; Child; Child Nutrition; Childhood; Chinese American; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Data; Development; Digestive System Disorders; Disease; Eating Behavior; Educational process of instructing; Enrollment; Environment; Environment Design; Environmental Exposure; Epidemiology; Etiology; Event; Fostering; Future; Gastroenterology; Goals; Hispanics; Infant; Inflammatory Bowel Diseases; Investigation; Knowledge; Latino; Manuscripts; Measurement; Mentors; Methodology; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Modeling; Natural History; Obesity; Oral; Patients; Postdoctoral Fellow; Publications; Quality of life; Research; Research Personnel; Research Project Grants; Research Training; San Francisco; Scholarship; School-Age Population; Structure; Supervision; Training Programs; Translational Research; United States National Institutes of Health; Universities; base; career; cohort; demographics; design; experience; interest; mother nutrition; nutrition; pediatric department; posters; pre-doctoral; programs; treatment strategy

DESCRIPTION (provided by applicant): This application to renew my K24 Midcareer Investigator Award in Patient-Oriented Research is based on research and teaching programs in pediatric inflammatory bowel disease (IBD) and pediatric nutrition at the University of California in San Francisco. Large cohorts of pediatric IBD patients are available at UCSF, augmented via collaborations with the Pediatric IBD Consortium in other IBD centers across the USA and within California. Ongoing IBD investigations include studies of the etiology of IBD utilizing the pediatric patient as a model for environmental exposures much less impacted by extraneous events compared with adults, the natural history of IBD beginning in childhood, particularly in those under six years of age, development of new strategies for treatment of pediatric IBD, and measurement of the quality of life in these subjects. Projects relating to pediatric nutrition focus on two main themes: assessing the influences of maternal nutrition knowledge and acculturation in Latino/Hispanic and Chinese-American children, taking advantage of the multi-ethnic demographics in the San Francisco Bay area to study development of eating behaviors and obesity in infants, young children and school age children. The influence of nutrition in various disease states is also under investigation. Trainees interested in pediatric gastroenterology and nutrition is encouraged to become directly involved in these clinical research training opportunities. The mentoring plan utilizes these projects to attract young investigators into the NIH-supported Research Training Program in Pediatric Gastroenterology and Nutrition (T32 DK 007762-28, PI Heyman). Structured mentoring is made available under my guidance, and trainees may enroll in coursework in the UCSF Masters in Clinical Research mentoring program that provides a well-designed environment for integration of epidemiological and biostatistical methodologies into clinical investigations. Additionally, trainees are provided with guidance and supervision by the Department of Pediatrics Scholarship Oversight Committee, which assures appropriate levels of mentoring and academic progress for the trainees. Trainees under my direct supervision are encouraged and assisted in designing and implementing research projects, analyzing resultant data, organizing oral/poster presentations, and preparing manuscripts for publication. In this enriched environment, trainees are stimulated to prepare for academic careers. The K24 award provides me with essential support for these educational and investigational efforts.

描述（由申请人提供）： 本申请更新我的K24职业中期研究者奖以患者为导向的研究是基于在弗朗西斯科的加州大学的儿科炎症性肠病（IBD）和儿科营养的研究和教学计划。在UCSF，通过与美国和加州其他IBD中心的儿科IBD联盟合作，可获得大量的儿科IBD患者。正在进行的IBD研究包括IBD的病因学研究，使用儿科患者作为与成人相比受外部事件影响更小的环境暴露模型，IBD的自然史始于儿童，特别是6岁以下儿童，开发治疗儿科IBD的新策略，并测量这些受试者的生活质量。与儿科营养相关的项目集中在两个主题：评估母亲营养知识和文化适应对拉丁裔/西班牙裔和华裔美国儿童的影响，利用弗朗西斯科湾区的多种族人口统计数据研究婴儿，幼儿和学龄儿童的饮食行为和肥胖的发展。营养对各种疾病状态的影响也在调查之中。鼓励对儿科胃肠病学和营养感兴趣的学员直接参与这些临床研究培训机会。指导计划利用这些项目来吸引年轻的研究人员参加NIH支持的儿科胃肠病学和营养研究培训计划（T32 DK 007762-28，PI Heyman）。在我的指导下提供结构化的指导，学员可以参加UCSF临床研究硕士指导计划的课程，该计划为流行病学和生物统计方法融入临床研究提供了精心设计的环境。此外，学员提供指导和监督由儿科奖学金监督委员会的部门，这保证了适当的指导和学员的学术进步水平。在我的直接监督下，鼓励和协助学员设计和实施研究项目，分析结果数据，组织口头/海报演示，并准备出版手稿。在这个丰富的环境中，学员被激励为学术生涯做准备。K24奖为我的这些教育和研究工作提供了必要的支持。

项目成果

The Active Balance Childhood program for improving coping and quality of life in Chinese American children.

• DOI: 10.1097/nnr.0b013e3181e507c7
• 发表时间: 2010-07
• 期刊: Nursing research
• 影响因子: 2.5
• 作者: Chen JL;Weiss SJ;Heyman MB;Cooper B;Lustig RH
• 通讯作者: Lustig RH

Pilot study of an individually tailored educational program by mail to promote healthy weight in Chinese American children.

• DOI: 10.1111/j.1744-6155.2008.00155.x
• 发表时间: 2008-07
• 期刊: Journal for specialists in pediatric nursing : JSPN
• 作者: Chen JL;Weiss S;Heyman MB;Vittinghoff E;Lustig R
• 通讯作者: Lustig R

Use of food labels, awareness of nutritional programmes and participation in the special supplemental program for Women, Infants and Children (WIC): results from the National Health and Nutrition Examination Survey (2005-2006).

食品标签的使用、对营养计划的认识以及参与妇女、婴儿和儿童特别补充计划（WIC）：国家健康和营养检查调查（2005-2006 年）的结果。

• DOI: 10.1111/j.1740-8709.2011.00382.x
• 发表时间: 2013
• 期刊: Maternal & child nutrition
• 影响因子: 3.4
• 作者: Wojcicki,JanetM;Heyman,MelvinB
• 通讯作者: Heyman,MelvinB

The use of decision analytic models to inform clinical decision making in the management of hepatocellular carcinoma.

使用决策分析模型为肝细胞癌治疗中的临床决策提供信息。

• DOI: 10.1016/j.cld.2004.12.004
• 发表时间: 2005
• 期刊: Clinics in liver disease.
• 作者: Kim,WRay

Sharp recanalization of a short esophageal occluding stricture in a patient with epidermolysis bullosa.

大疱性表皮松解症患者短食管闭塞狭窄的急剧再通。

• DOI: 10.1016/j.gie.2006.07.029
• 发表时间: 2006
• 期刊: Gastrointestinal endoscopy
• 影响因子: 7.7
• 作者: Thornton,RaymondH;Heyman,MelvinB;Wilson,MarkW;Zarrinpar,Ali;Kerlan,RobertK;LaBerge,JeanneM;Zwass,Maurice;Gordon,RoyL
• 通讯作者: Gordon,RoyL