Applications of nanodiamond for adaptive-optics corrected super-resolution imaging

纳米金刚石在自适应光学校正超分辨率成像中的应用

• 批准号: 2434697
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2434697
• 关键词: Applications; nanodiamond; adaptive; optics; corrected

Super-resolution imaging techniques allow studying of structures much smaller than the traditional limit of approximately half the wavelength of the light. The 2014 Nobel Prize in Chemistry has emphasised its fundamental importance to the biological sciences. We develop microscopes that can perform super-resolution imaging within biological samples; however there are still numerous challenges to successful imaging such as the effects of optical inhomogeneities on the imaging process, effective labelling of structures of interest with suitable dyes and the desire to further increase speed of acquisition, field of view, resolution and perform multi-colour imaging in 3D.The successful student will have the opportunity to develop a wide range of skills that are essential for performing research into next-generation microscopy, e.g. developing nanodiamond as an optical sensor in living tissue and the use of adaptive optics to correct for aberrations in biologically relevant samples. Successful candidates will gain a wide range of experience in skills such as: Optical hardware design and alignment, developing software for hardware control and data processing, labelling samples for imaging and collaboration with colleagues in the biological sciences to ensure our research also enables new biological science.

超分辨率成像技术可以研究比传统限制小得多的结构，即大约一半的光波长。2014年诺贝尔化学奖强调了它对生物科学的根本重要性。我们开发的显微镜可以在生物样本中执行超分辨率成像；然而，成功的成像仍然面临许多挑战，例如光学不均匀对成像过程的影响，使用合适的染料有效标记感兴趣的结构，以及进一步提高采集速度、视野、分辨率和在3D中执行多色成像的愿望。成功的学生将有机会发展广泛的技能，这些技能对于进行下一代显微镜的研究是必不可少的，例如，开发纳米钻石作为生物组织中的光学传感器，以及使用自适应光学来纠正与生物相关的样本中的像差。成功的候选人将获得广泛的技能方面的经验，如：光学硬件设计和对准、开发硬件控制和数据处理软件、标记成像样品以及与生物科学同行合作，以确保我们的研究也能实现新的生物科学。