Translation in the 3' UTR and its role in the post-transcriptional regulation of gene expression.

众所周知，mRNAs中的非翻译区(UTRs)包含基因表达的调控因子，包括序列元件、结构和上游开放阅读框架。最近，下游开放阅读框架(DORF)作为潜在的翻译调节因子受到了关注，尽管人们对它们知之甚少。该项目将结合生物信息学和基于实验室的方法来研究UTRs下游的开放阅读框架和其他调控元件，以及这些元件在疾病中可能如何失调。

Untranslated regions (UTRs) in mRNAs are well known to contain regulators of gene expression, including sequence elements, structures, and upstream open reading frames. Very recently, downstream open reading frames (dORFs) have gained attention as potential regulators of translation, although very little is yet known about them. This project will combine bioinformatic and laboratory-based approaches to investigate downstream open reading frames and other regulatory elements in UTRs, and how these might be dysregulated in disease.