ACISR for Pediatric Psychiatry Disorders

ACISR 儿童精神疾病

• 批准号: 6812804
• 负责人: DAVID SHAFFER
• 金额: $ 145.24万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-21 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6812804
• 关键词: biomedical facility; child mental disorders; child mental health service; clinical research; human subject; pediatrics; psychiatry

DESCRIPTION (provided by applicant): The proposal outlines four cores that will work with another towards the following goals: 1) To promote and develop efficacy studies in disorders of interest to investigators of the Center where the evidence-based support for interventions remains substantially deficient and where "export" into the field would be premature. 2) To study of transportability and effectiveness of interventions or methods of evaluation for which there is substantial evidence-based support, to real world settings. 3) To identify problems in the methods used in intervention research with children and adolescents. 4) To work with basic-scientists to investigate whether state of the art imaging and genotyping methods can be used to identify the mediators of treatment response. 5) To train new intervention researchers; and 6) to take a scientific and advocacy leadership role in promoting and disseminating intervention research. The cores are as follows: Principal Research Core (M. Weissman), will set the research agenda for the center. The PRC will consultant, develop and conduct studies aimed at developing intervention (psychosocial, pharmacological, and combination) knowledge for disorders of interest to the center. It will exercise this influence by consultation services, training activities and a pilot funding mechanism which will solicit, review, shape, implement and monitor projects with the potential to advance the scientific aims of the center. The Operations Core's (B. Waslick) primary tasks are to attend to the necessary administrative issues as well as to promote and implement several aspects of the scientific program including recruitment of subjects for research protocols, screening, administration of a core battery of measures, overall scientific and training agenda developed in the PRC. The Research Network Development Core (P. Jensen) will develop an infrastructure that will permit a variety of research activities to be conducted in existing community based services: school based clinics and pediatric practices with an interest in mental health problems. These provide ideal settings to take intervention approaches that have good clinical trial-based efficacy support and study their effectiveness in real world settings. The Research Methods Core (D. Shaffer) will conduct or sponsor measurement projects that are pertinent to the center's goals and will draw into the center basic scientists who will, for the first time, study some possible modifiers of treatment response.

描述（由申请人提供）：该提案概述了四个核心，将与另一个核心合作实现以下目标：1）促进和发展中心研究人员感兴趣的疾病的疗效研究，其中对干预措施的循证支持仍然严重不足，并且“出口”到该领域还为时过早。2)研究干预措施或评估方法的可移植性和有效性，这些措施或方法有大量的循证支持，适用于真实的世界环境。3)找出儿童和青少年干预研究方法中存在的问题。4)与基础科学家合作，研究最先进的成像和基因分型方法是否可用于识别治疗反应的介质。5)培训新的干预研究人员; 6）在促进和传播干预研究方面发挥科学和倡导领导作用。核心如下：主要研究核心（M。Weissman）将为该中心制定研究议程。PRC将提供咨询、开发和开展研究，旨在开发中心关注的疾病的干预（社会心理、药理学和组合）知识。它将通过咨询服务、培训活动和试点供资机制来发挥这种影响力，该机制将征集、审查、制定、实施和监测有可能推进中心科学目标的项目。运营核心（B. Waslick）的主要任务是处理必要的行政问题，以及促进和实施科学计划的几个方面，包括招募研究方案的受试者、筛选、核心措施的管理、中国制定的整体科学和培训议程。研究网络发展核心（P.詹森）将开发一个基础设施，允许在现有的社区服务中开展各种研究活动：学校诊所和对心理健康问题感兴趣的儿科实践。这些提供了理想的设置，以采取具有良好的基于临床试验的疗效支持的干预方法，并研究其在真实的世界环境中的有效性。研究方法核心（D。谢弗）将进行或赞助与中心目标有关的测量项目，并将吸引基础科学家进入中心，他们将首次研究一些可能的治疗反应调节剂。