Core Grant For Vision Research

描述(由申请人提供)：这份P30提案申请资金，以支持匹兹堡大学眼耳研究所眼科学和视觉科学研究中心(OVSRC)内五个资源模块的运行。OVSRC为匹兹堡大学3个系和卡内基梅隆大学1个系的17名视觉科学家的基础和临床视力研究提供了一个大本营，他们的工作是推进角膜、白内障、青光眼、感觉、运动、视网膜和其他眼部疾病的知识库。其中，11个是由NEI资助的(拥有13个R01赠款、2个R03赠款、1个合同和3个分包合同)，3名调查人员由其他NIH研究所资助，其余的调查人员由私人资助机构资助。核心赠款模块主要支持NEI资助的研究人员，以及正在进行最终将导致NEI支持的研究的新调查人员。OVSRC核心赠款参与者的科学学科包括细胞生物学、细胞信号、病毒学、免疫学、发育生物学、分子遗传学、神经生物学、电生理学和眼睛成像。核心资助模块旨在提供支持这些科学学科的技术，包括：1)电子学和图像获取和分析，2)基因表达和蛋白质组学，3)杂交瘤和组织培养，4)分子生物学，5)形态学。所有模块都集中在OVSRC内，位于眼耳研究所的9层和10层。在第14个年头，Core Grant继续加强匹兹堡地区的视力研究，提供尖端技术，促进将该技术纳入研究项目，并促进基础科学家和内科科学家之间的合作。

DESCRIPTION (provided by applicant): This P30 proposal requests funding to support the operation of five resource modules within the Ophthalmology and Visual Sciences Research Center (OVSRC) at the Eye and Ear Institute of the University of Pittsburgh. The OVSRC provides a home base for the basic and clinical vision research of 17 vision scientists in 3 departments of the University of Pittsburgh and one department of Carnegie Mellon University, whose work is advancing the knowledge base on corneal, cataract, glaucoma, sensory, motor, retinal and other eye diseases. Of these, 11 are NEI-funded (holding 13 R01 grants, 2 RO3 grants, 1 contract, and 3 subcontracts), 3 investigators are funded through other NIH institutes, and the remaining investigators are funded through private funding agencies. The core grant modules primarily support the NEI-funded investigators, and new investigators who are conducting research that will lead ultimately to NEI support. The scientific disciplines of the OVSRC core grant participants include cell biology, cell signaling, virology, immunology, developmental biology, molecular genetics, neurobiology, electrophysiology, and ocular imaging. The core grant modules are designed to provide technologies that support these scientific disciplines, and include: 1) electronics and image acquisition and analysis, 2) gene expression and proteomics, 3) hybridoma and tissue culture, 4) molecular biology, and 5) morphology. All modules are centrally housed within the OVSRC on the 9th and 10th floors of the Eye and Ear Institute. In its 14th year, the Core Grant continues to enhance vision research in the Pittsburgh area by providing cutting edge technology, facilitating the incorporation of that technology into research projects, and facilitating collaboration among basic scientists and physician scientists.