Core Grant For Vision Research

描述（由申请人提供）：本P30提案请求资助，以支持匹兹堡大学眼耳研究所眼科和视觉科学研究中心（OVSRC）内五个资源模块的运作。OVSRC为匹兹堡大学3个院系和卡内基梅隆大学1个院系的17位视觉科学家提供了基础和临床视觉研究的基地，他们的工作是推进角膜、白内障、青光眼、感觉、运动、视网膜和其他眼病的知识库。其中，11名是nei资助的（持有13个R01资助，2个RO3资助，1个合同和3个分包合同），3名研究人员由其他NIH机构资助，其余研究人员由私人资助机构资助。核心拨款模块主要支持NEI资助的研究人员，以及正在进行最终将获得NEI支持的研究的新研究人员。OVSRC核心资助参与者的科学学科包括细胞生物学、细胞信号学、病毒学、免疫学、发育生物学、分子遗传学、神经生物学、电生理学和眼成像。核心资助模块旨在提供支持这些科学学科的技术，包括：1)电子学和图像采集与分析，2)基因表达和蛋白质组学，3)杂交瘤和组织培养，4)分子生物学，5)形态学。所有模块都集中在眼耳研究所的9楼和10楼的OVSRC内。在其第14个年头，核心赠款通过提供尖端技术，促进将该技术纳入研究项目以及促进基础科学家和医师科学家之间的合作，继续加强匹兹堡地区的视觉研究。

DESCRIPTION (provided by applicant): This P30 proposal requests funding to support the operation of five resource modules within the Ophthalmology and Visual Sciences Research Center (OVSRC) at the Eye and Ear Institute of the University of Pittsburgh. The OVSRC provides a home base for the basic and clinical vision research of 17 vision scientists in 3 departments of the University of Pittsburgh and one department of Carnegie Mellon University, whose work is advancing the knowledge base on corneal, cataract, glaucoma, sensory, motor, retinal and other eye diseases. Of these, 11 are NEI-funded (holding 13 R01 grants, 2 RO3 grants, 1 contract, and 3 subcontracts), 3 investigators are funded through other NIH institutes, and the remaining investigators are funded through private funding agencies. The core grant modules primarily support the NEI-funded investigators, and new investigators who are conducting research that will lead ultimately to NEI support. The scientific disciplines of the OVSRC core grant participants include cell biology, cell signaling, virology, immunology, developmental biology, molecular genetics, neurobiology, electrophysiology, and ocular imaging. The core grant modules are designed to provide technologies that support these scientific disciplines, and include: 1) electronics and image acquisition and analysis, 2) gene expression and proteomics, 3) hybridoma and tissue culture, 4) molecular biology, and 5) morphology. All modules are centrally housed within the OVSRC on the 9th and 10th floors of the Eye and Ear Institute. In its 14th year, the Core Grant continues to enhance vision research in the Pittsburgh area by providing cutting edge technology, facilitating the incorporation of that technology into research projects, and facilitating collaboration among basic scientists and physician scientists.