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Research Integrity & Financial Conflicts of Interest

研究诚信

基本信息

批准号：
6801160
负责人：
PATRICIA Miller TERESKERZ
金额：
$ 14.44万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-15 至 2007-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6801160
关键词：
behavioral /social science research tag clinical research conflict education cost /financing ethics health science profession health science research support human subject mathematical model population survey socioeconomics statistics /biometry

项目摘要

DESCRIPTION (provided by the applicant): This research would represent the first national study of multiple parameters of financial conflicts-of-interest, and how they may be correlated with practices thought to impact the integrity of research. Data from this project would inform the committee of new policy recommendations by identifying, for the first time, those arrangements that are associated with, or which best predict when an investigator may engage in conduct that may impact the integrity of research. This will allow for a better allocation of future resources to address those arrangements that are in the greatest need of regulatory oversight and/or educational initiatives. The research is innovative, in that the focus is on practices of investigators, rather than upon institutional policies, and would provide the first national data on financial conflicts-of-interest in both the medical and nursing school settings. Industry-funded research is the sole focus of this proposal. National surveys of life-science faculty at medical and nursing schools will be conducted to accomplish the following specific aims: 1) Determine A) the national prevalence of various financial arrangements undertaken by investigators, that may constitute a financial conflict of interest; B) determine the national prevalence of various, questionable practices in the conduct and reporting of research; and C) survey investigator knowledge of policies governing financial conflicts-of-interest. Frequencies and descriptive statistics will be prepared for each relevant survey question, and will be reported taking into account the margin of error. 2) Determine if there is any difference between nursing and medical schools in A) the prevalence of financial arrangements that can give rise to conflicts-of-interest; B) in the prevalence of questionable integrity practices; and C) in the investigator knowledge of policies governing financial conflicts-of-interest. 3) Determine which financial arrangements are associated with specific, questionable integrity practices. Chi square tests will be used to ascertain the statistical significance of relationships between categorical questions. T-tests will be used to test for differences in means where appropriate. 4) Explore the utility of using data reduction techniques and appropriate, multi-variate modeling techniques to show which types of financial arrangements predict questionable integrity practices.

说明(由申请人提供)：这项研究将是对金融利益冲突的多个参数以及它们可能如何与被认为影响研究完整性的做法相关联的第一次全国性研究。该项目的数据将通过第一次确定与调查员何时可能从事可能影响研究完整性的行为有关的安排或最佳预测安排，向委员会通报新的政策建议。这将使今后能够更好地分配资源，以处理最需要监管监督和/或教育举措的安排。这项研究是创新的，因为重点是调查人员的做法，而不是制度政策，并将提供关于医疗和护理学校环境中的财务利益冲突的第一个国家数据。行业资助的研究是这项提议的唯一重点。将对医学院和护理学校的生命科学教师进行全国调查，以实现以下具体目标：1)确定A)调查人员作出的可能构成财务利益冲突的各种财务安排在全国的普遍程度；B)确定在进行和报告研究方面各种有问题的做法在全国的普遍程度；以及C)调查调查员对管理财务利益冲突的政策的了解。将为每个相关的调查问题准备频率和描述性统计数据，并将在考虑误差幅度的情况下进行报告。2)确定护理学校和医学院在以下方面是否存在差异：A)可能引起利益冲突的财务安排的普遍性；B)有问题的诚信做法的普遍性；以及C)调查员对管理财务利益冲突的政策的了解。3)确定哪些财务安排与具体的、有问题的诚信做法有关。卡方检验将被用来确定分类问题之间关系的统计意义。在适当的情况下，将使用t检验来检验方法上的差异。4)探索使用数据简化技术和适当的多变量建模技术的效用，以显示哪些类型的财务安排预测了有问题的诚信做法。