Research Integrity & Financial Conflicts of Interest

研究诚信

• 批准号: 6684643
• 负责人: PATRICIA Miller TERESKERZ
• 金额: $ 14.44万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6684643
• 关键词: behavioral /social science research tag; clinical research; conflict; education cost /financing; ethics; health science profession; health science research support; human subject; mathematical model; population survey; socioeconomics; statistics /biometry

DESCRIPTION (provided by the applicant): This research would represent the first national study of multiple parameters of financial conflicts-of-interest, and how they may be correlated with practices thought to impact the integrity of research. Data from this project would inform the committee of new policy recommendations by identifying, for the first time, those arrangements that are associated with, or which best predict when an investigator may engage in conduct that may impact the integrity of research. This will allow for a better allocation of future resources to address those arrangements that are in the greatest need of regulatory oversight and/or educational initiatives. The research is innovative, in that the focus is on practices of investigators, rather than upon institutional policies, and would provide the first national data on financial conflicts-of-interest in both the medical and nursing school settings. Industry-funded research is the sole focus of this proposal. National surveys of life-science faculty at medical and nursing schools will be conducted to accomplish the following specific aims: 1) Determine A) the national prevalence of various financial arrangements undertaken by investigators, that may constitute a financial conflict of interest; B) determine the national prevalence of various, questionable practices in the conduct and reporting of research; and C) survey investigator knowledge of policies governing financial conflicts-of-interest. Frequencies and descriptive statistics will be prepared for each relevant survey question, and will be reported taking into account the margin of error. 2) Determine if there is any difference between nursing and medical schools in A) the prevalence of financial arrangements that can give rise to conflicts-of-interest; B) in the prevalence of questionable integrity practices; and C) in the investigator knowledge of policies governing financial conflicts-of-interest. 3) Determine which financial arrangements are associated with specific, questionable integrity practices. Chi square tests will be used to ascertain the statistical significance of relationships between categorical questions. T-tests will be used to test for differences in means where appropriate. 4) Explore the utility of using data reduction techniques and appropriate, multi-variate modeling techniques to show which types of financial arrangements predict questionable integrity practices.

描述（由申请人提供）：这项研究将代表第一次对财务利益冲突的多个参数进行全国性研究，以及它们如何与被认为会影响研究完整性的实践相关联。 该项目的数据将通过首次确定与研究者可能从事可能影响研究完整性的行为相关的安排或最佳预测这些安排，为委员会提供新的政策建议。 这将有助于更好地分配未来资源，以处理最需要监管监督和/或教育举措的安排。 这项研究是创新的，因为重点是调查人员的做法，而不是机构政策，并将提供第一个国家的数据，在医疗和护理学校的设置财务利益冲突。 工业资助的研究是这项建议的唯一重点。 将对医学院和护理学校的生命科学教师进行全国调查，以实现以下具体目标：1）确定A）调查人员所采取的各种财务安排在全国的普遍性，这些安排可能构成财务利益冲突; B）确定研究进行和报告中各种可疑做法在全国的普遍性;以及C）调查研究者对管理财务利益冲突的政策的了解。 将为每个相关的调查问题准备频率和描述性统计数据，并将在考虑误差幅度的情况下报告。 2)确定护理学校和医学院在以下方面是否存在差异：A）可能导致利益冲突的财务安排的普遍性; B）可疑诚信实践的普遍性;以及C）研究者对管理财务利益冲突的政策的了解。 3)确定哪些财务安排与具体的、有问题的诚信做法有关。 卡方检验将用于确定分类问题之间关系的统计学显著性。 在适当情况下，将使用T检验检验平均值差异。 4)探索使用数据简化技术和适当的多变量建模技术的实用性，以显示哪些类型的财务安排预测可疑的完整性做法。