Tissue Engineering Design of Novel Bio-Therapeutics for Cancer Treatment

用于癌症治疗的新型生物疗法的组织工程设计

• 批准号: 2435449
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2435449
• 关键词: Tissue; Engineering; Design; Novel; Bio

One novel idea for a cancer therapeutic is to use tissue engineering to stop tumour growth and progression of the cancer as it spreads, for example, through creation of a biological patch which can encapsulate the tumour, thus preventing any further growth or metastasis. By careful consideration of the conditions and materials to be used, scaffolds can be created that could control the shape and size of the tumour, and which have potential to be designed to incorporate a range of biomolecules such as growth factors to proteins. This idea could be further developed into a potential method for drug delivery by adding an anti-cancer drug to the engineered patch so that it would not only prevent further tumour growth but also deliver the drug directly to the tumour site. If successful, this could provide a much-needed breakthrough in cancer treatment, with direct targeting of the tumour and reducing the unpleasant side effects associated with current therapeutics. It would also offer a more accurate three-dimensional insight into the tumour environment, compared to current studies which look at two-dimensional cell studies, which are an inaccurate representation of the tumour environment.

癌症治疗的一个新想法是使用组织工程来阻止肿瘤的生长和癌症的进展，因为它扩散，例如，通过创建可以包裹肿瘤的生物补丁，从而防止任何进一步的生长或转移。通过仔细考虑使用的条件和材料，可以创建可以控制肿瘤形状和大小的支架，并且可以设计成将一系列生物分子（如生长因子）掺入蛋白质。这一想法可以进一步发展成为一种潜在的药物递送方法，方法是在工程补丁中添加抗癌药物，这样不仅可以防止肿瘤进一步生长，还可以将药物直接递送到肿瘤部位。如果成功，这将为癌症治疗提供急需的突破，直接靶向肿瘤并减少与当前疗法相关的不良副作用。它还将提供对肿瘤环境的更准确的三维洞察，与目前研究二维细胞研究相比，这是对肿瘤环境的不准确表示。