权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Design of polymers and bioreactors in the development of a tissue engineering strategy for degenerative disc disease

退行性椎间盘疾病组织工程策略开发中的聚合物和生物反应器设计

基本信息

批准号：
RGPIN-2015-05179
负责人：
Amsden, Brian
金额：
$ 2.55万
依托单位：
Queen's University
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2017
资助国家：
加拿大
起止时间：
2017-01-01 至 2018-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=637950
关键词：
Design polymers bioreactors development tissue

项目摘要

The major challenge addressed in the proposed program is the design, synthesis, and testing of new polymeric biomaterials and bioreactors to be used for the development of a new treatment for degenerative intervertebral disc disease. The intervertebral disc is the connective tissue between the vertebral bones of the spine. It holds the verterbrae together, absorbs compressive loads, and allows the spine to rotate, bend, and twist. Degeneration of the intervertebral disc is a common source of chronic pain and reduced quality of life in people over the age of 40. About 12 million patients are diagnosed with this condition annually in North America. Treatment is typically palliative; however, in ~ 10% of these patients, surgery is ultimately necessary. Current surgical methods provide temporary relief, and do not repair the damaged disc. A treatment methodology is proposed that involves removing the degenerating tissue, and replacing it with regenerative cells delivered within a polymer biomaterial that can form a cell supportive depot while providing mechanical support to the damaged disc. The regenerative cells will ultimately produce replacement tissue while at the same time the polymer biomaterial degrades. The regenerative cells will be obtained from stem cells isolated from fat. These stem cells will be induced to become cells typical of the centre of the intervertebral disc (nucleus pulposus cells) in a bioreactor for this purpose

在拟议的项目中解决的主要挑战是设计、合成和测试新的聚合物生物材料和生物反应器，用于开发退行性椎间盘疾病的新治疗方法。椎间盘是脊柱椎骨之间的结缔组织。它将椎骨固定在一起，吸收压缩载荷，并允许脊柱旋转、弯曲和扭曲。椎间盘退变是40岁以上人群慢性疼痛和生活质量下降的常见原因。在北美，每年约有1200万患者被诊断出患有这种疾病。治疗通常是姑息性的；然而，其中约10%的患者最终需要手术。目前的手术方法提供了暂时的缓解，并不能修复受损的椎间盘。提出了一种治疗方法，包括去除退化组织，用再生细胞代替，再生细胞在聚合物生物材料中传递，可以形成细胞支持库，同时为受损椎间盘提供机械支持。再生细胞最终将产生替代组织，同时高分子生物材料降解。再生细胞将从从脂肪中分离出来的干细胞中获得。这些干细胞将在生物反应器中被诱导成为椎间盘中心的典型细胞（髓核细胞）