Double Jeopardy: Cognitive Decline in Depression & Aging

双重危险：抑郁症的认知能力下降

• 批准号: 6828710
• 负责人: Vonetta M Dotson
• 金额: $ 3.34万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6828710
• 关键词: age difference; aging; behavior test; behavioral /social science research tag; cingulate gyrus; clinical depression; clinical research; cognition disorders; comorbidity; cues; electroencephalography; electrooculography; human old age (65+); human subject; young adult human (21-34)

DESCRIPTION (provided by applicant): Depressive symptoms are prevalent adults, and both aging and depression are independently associated with impairments in cognitive functioning, particularly in the domain of "executive" control. The primary aim of this project is to determine if older depressed adults are at "double jeopardy" for executive dysfunction due to an additive or multiplicative effect of aging and depressive symptoms. Study methods will examine younger (ages 18-30) and older (ages 65-80) adults while performing a novel cognitive task designed to temporally dissociate components of cognitive control. High-density event-related potentials (ERPs) will be used to dissociate strategic processes supporting the implementation of cognitive control, and evaluative processes supporting the detection of processing conflicts and performance monitoring. The specific aims are to: 1) determine if aging and depressive symptoms are associated with declines in cognitive control as assessed using a "cued-Stroop" task; 2) temporally and anatomically dissociate component processes associated with cognitive control using ERPs and determine if aging and depression differentially affect these processes; and 3) determine if the combined effect of aging and depression on cognitive control is additive or multiplicative. The specific hypotheses motivating the proposed research are that: 1) both increasing age and depressive symptoms contribute to declines in cued-Stroop performance; 2) increasing age is associated with impairments in strategic aspects of cognitive control (mediated by the dorsolateral prefrontal cortex), and depressive symptoms are associated with impaired evaluative processes (mediated by the anterior cingulate cortex); and 3) older depressed adults exhibit significantly greater declines in cognitive control than older non-depressed adults or young depressed adults. Accomplishing the aims outlined in this proposal will provide the foundation for future studies examining the effect of aging and depression on cognition and activities of daily living.

描述（由申请人提供）：抑郁症状在成年人中普遍存在，并且衰老和抑郁都与认知功能损伤独立相关，特别是在“执行”控制领域。该项目的主要目的是确定老年抑郁症患者是否因衰老和抑郁症状的累加或相乘效应而面临执行功能障碍的“双重危险”。研究方法将检查年轻人（18-30 岁）和老年人（65-80 岁），同时执行一项新颖的认知任务，该任务旨在暂时分离认知控制的各个组成部分。高密度事件相关电位（ERP）将用于分离支持认知控制实施的战略过程和支持处理冲突检测和绩效监控的评估过程。具体目标是：1）确定衰老和抑郁症状是否与使用“cued-Stroop”任务评估的认知控制能力下降有关； 2）使用ERP在时间上和解剖上分离与认知控制相关的组成过程，并确定衰老和抑郁是否对这些过程有不同的影响； 3）确定衰老和抑郁对认知控制的综合影响是加法还是乘法。促进本研究的具体假设是：1）年龄的增长和抑郁症状都会导致提示斯特鲁普表现的下降； 2） 年龄的增长与认知控制的战略方面的损害（由背外侧前额叶皮层介导）有关，抑郁症状与评估过程受损（由前扣带皮层介导）有关； 3）老年抑郁症患者的认知控制能力比老年非抑郁症患者或年轻抑郁症患者表现出明显更大的下降。实现该提案中概述的目标将为未来研究衰老和抑郁对认知和日常生活活动的影响奠定基础。