Innovative MRI Research Technology

创新的 MRI 研究技术

• 批准号: 6779120
• 负责人: PAUL A BOTTOMLEY
• 金额: $ 77.53万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6779120
• 关键词: animal tissue; biomedical equipment development; cardiovascular disorder diagnosis; clinical research; human subject; image guided surgery /therapy; magnetic resonance imaging; method development; myocardial ischemia /hypoxia; nervous system disorder diagnosis; phantom model; radiation therapy; radiowave radiation; stroke

DESCRIPTION (Provided by Applicant): New advances in magnetic resonance imaging (MRI) show enormous potential for a broad range ot new clinical and research applications including high-speed cardiovascular imaging, functional brain imaging, and contrast-sensitive image-guided intervention. They promise important advances in the assessment and treatment of cardiovascular disease, cancer and brain function. Central to their success are the dual demands of imaging speed and signal-to-noise ratio (SNR). Core biotechnology research that significantly advances MRJ speed and SNR are pivotal to progress and could impact new MRI applications across-the-board. This proposal, responsive to PAR-99-009 for Bioengineering Research, will directly advance MRI speed and SNR with innovative research in fourkey areas: the MRI gradient systems; high-speed multi-channel MRI receivers; new high-speed relaxation time (Ti) measurements and imaging; and the design of MRI detector coil systems that deliver the ultimate intrinsic SNR (UISNR)-the maximum that can be had. Specifically, we propose to develop compact, highly-efficient surface MRI gradient modules that can significantly increase gradient strength by more than an order of magnitude, and reduce gradient rise-times, and to develop algorithms to correct gradient nonlinearity. We will demonstrate the gradient advantages in a pilot study of diffusion MRI in acutestroke. We will develop a high-speed multi-channel receiver system with new analytic reconstruction methods for sensitivity-encoding to achieve manifold reductions in the minimum scan-time, and to realize the speed gains from the other projects, and we will demonstrate this with real-time MRT stress-testing of patients with ischemia. Ti relaxation is key to MRI contrast, and we propose new methods that promise dramatic reductions in Ti measurement times, Ti imaging, and we will demonstrate its potential for temperature monitoring during RF ablation therapy. andin human Ti studies. Finally, we introduced the USINR concept, and will now develop tools for designing coils that yield the UISNR, and build them for the head, heart, and abdomen, and will compare their performance to existingcoils. We hypothesize that the integration of radical redesigns of gradient, MRI detector coils, and high-speed contrast-sensitive MRI, will yield simultaneous performance gains that will provide truly new opportunities for clinical diagnostic and interventional research. The work will be implemented at 1 .5T and will directly and positively benefit 21 other funded research grants at this institution, with broad potential benefit to noninvasive imaging in a wide range of patients and diseases.

描述（由申请人提供）：磁共振成像的新进展 (MRI)显示出巨大潜力，可用于广泛的新临床和研究 应用包括高速心血管成像、功能性脑 成像和对比敏感的图像引导介入。他们承诺 心血管疾病评估和治疗的重要进展， 癌症和大脑功能他们成功的核心是双重要求， 成像速度和信噪比（SNR）。核心生物技术研究， 显著提高MRJ速度和SNR是取得进展的关键， 全面影响新的MRI应用。这项建议，响应 用于生物工程研究的PAR-99-009将直接提高MRI速度和SNR 在四个关键领域进行创新研究：MRI梯度系统;高速 多通道MRI接收器;新的高速弛豫时间（Ti）测量 和成像;以及MRI探测器线圈系统的设计， 极限固有SNR（UISNR）-可以具有的最大值。我们特别 建议开发紧凑、高效的表面MRI梯度模块， 可以显著地增加梯度强度， 幅度，并减少梯度上升时间，并制定算法，以纠正 梯度非线性我们将在试点中展示梯度优势 急性脑卒中磁共振弥散成像研究我们将开发高速 具有新的解析重构方法的多信道接收机系统 灵敏度编码以在最小扫描时间内实现多方面的减少， 并实现其他项目的速度增益，我们将演示 这是对缺血患者进行实时MRT压力测试。t1弛豫 是MRI对比度的关键，我们提出了新的方法， 减少钛测量时间，钛成像，我们将证明其 在射频消融治疗期间进行温度监测的可能性。在人Ti 问题研究最后，我们介绍了USINR概念，现在将开发工具 用于设计产生UISNR的线圈，并为头部、心脏 和腹部，并将其性能与现有线圈进行比较。我们 假设梯度、MRI探测器的彻底重新设计的集成 线圈，和高速对比敏感的MRI，将产生同时 性能提升将为临床应用提供真正的新机遇 诊断和干预研究。该工作将在1.5T实施 并将直接和积极地受益于21个其他资助的研究赠款， 该机构，具有广泛的潜在利益，在广泛的非侵入性成像 患者和疾病的范围。