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Innovative MRI Research Technology

创新的 MRI 研究技术

基本信息

批准号：
6932391
负责人：
PAUL A BOTTOMLEY
金额：
$ 77.45万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-30 至 2008-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6932391
关键词：
animal tissue biomedical equipment development cardiovascular disorder diagnosis clinical research human subject image guided surgery /therapy magnetic resonance imaging method development myocardial ischemia /hypoxia nervous system disorder diagnosis phantom model radiation therapy radiowave radiation stroke

项目摘要

DESCRIPTION (Provided by Applicant): New advances in magnetic resonance imaging (MRI) show enormous potential for a broad range ot new clinical and research applications including high-speed cardiovascular imaging, functional brain imaging, and contrast-sensitive image-guided intervention. They promise important advances in the assessment and treatment of cardiovascular disease, cancer and brain function. Central to their success are the dual demands of imaging speed and signal-to-noise ratio (SNR). Core biotechnology research that significantly advances MRJ speed and SNR are pivotal to progress and could impact new MRI applications across-the-board. This proposal, responsive to PAR-99-009 for Bioengineering Research, will directly advance MRI speed and SNR with innovative research in fourkey areas: the MRI gradient systems; high-speed multi-channel MRI receivers; new high-speed relaxation time (Ti) measurements and imaging; and the design of MRI detector coil systems that deliver the ultimate intrinsic SNR (UISNR)-the maximum that can be had. Specifically, we propose to develop compact, highly-efficient surface MRI gradient modules that can significantly increase gradient strength by more than an order of magnitude, and reduce gradient rise-times, and to develop algorithms to correct gradient nonlinearity. We will demonstrate the gradient advantages in a pilot study of diffusion MRI in acutestroke. We will develop a high-speed multi-channel receiver system with new analytic reconstruction methods for sensitivity-encoding to achieve manifold reductions in the minimum scan-time, and to realize the speed gains from the other projects, and we will demonstrate this with real-time MRT stress-testing of patients with ischemia. Ti relaxation is key to MRI contrast, and we propose new methods that promise dramatic reductions in Ti measurement times, Ti imaging, and we will demonstrate its potential for temperature monitoring during RF ablation therapy. andin human Ti studies. Finally, we introduced the USINR concept, and will now develop tools for designing coils that yield the UISNR, and build them for the head, heart, and abdomen, and will compare their performance to existingcoils. We hypothesize that the integration of radical redesigns of gradient, MRI detector coils, and high-speed contrast-sensitive MRI, will yield simultaneous performance gains that will provide truly new opportunities for clinical diagnostic and interventional research. The work will be implemented at 1 .5T and will directly and positively benefit 21 other funded research grants at this institution, with broad potential benefit to noninvasive imaging in a wide range of patients and diseases.

描述（由申请人提供）：磁共振成像的新进展（MRI）显示出广泛的新临床和研究的巨大潜力应用包括高速心血管成像、功能性大脑成像和对比敏感图像引导干预。他们承诺心血管疾病评估和治疗方面的重要进展，癌症和脑功能。他们成功的核心是双重要求成像速度和信噪比 (SNR)。核心生物技术研究显着提高 MRJ 速度和 SNR 是进步的关键，并且可以全面影响新的 MRI 应用。本提案响应用于生物工程研究的 PAR-99-009，将直接提高 MRI 速度和 SNR 在四个关键领域进行创新研究：MRI梯度系统；高速多通道 MRI 接收器；新的高速弛豫时间 (Ti) 测量和成像；以及 MRI 探测器线圈系统的设计，该系统可提供最终固有 SNR (UISNR) - 可以达到的最大值。具体来说，我们建议开发紧凑、高效的表面 MRI 梯度模块可以显着增加梯度强度超过一个数量级幅度，减少梯度上升时间，并开发算法来纠正梯度非线性。我们将在试点中展示梯度优势弥散磁共振成像在急性脑卒中的研究。我们将开发高速具有新的解析重建方法的多通道接收器系统灵敏度编码以实现最小扫描时间的多倍减少，并实现其他项目的速度增益，我们将展示这是通过对缺血患者进行实时 MRT 压力测试来实现的。钛弛豫是 MRI 对比的关键，我们提出了有望实现显着效果的新方法减少 Ti 测量时间、Ti 成像，我们将展示其射频消融治疗期间温度监测的潜力。人钛研究。最后，我们介绍了USINR的概念，现在将开发工具设计产生 UISNR 的线圈，并为头部、心脏、和腹部，并将其性能与现有线圈进行比较。我们假设梯度、MRI 探测器的彻底重新设计的整合线圈和高速对比敏感 MRI，将同时产生性能提升将为临床提供真正的新机会诊断和介入研究。该工作将在 1 .5T 下实施并将直接和积极地惠及其他 21 项资助的研究资助该机构对非侵入性成像具有广泛的潜在益处患者和疾病的范围。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Turning up the heat on MRI.

DOI：
10.1016/j.jacr.2008.04.003
发表时间：
2008-07
期刊：
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
影响因子：
4.5
作者：
Bottomley, Paul A
通讯作者：
Bottomley, Paul A

Measuring local RF heating in MRI: Simulating perfusion in a perfusionless phantom.

测量 MRI 中的局部射频加热：模拟无灌注模型中的灌注。

DOI：
10.1002/jmri.21161
发表时间：
2007
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
0
作者：
Akca,ImranB;Ferhanoglu,Onur;Yeung,ChristopherJ;Guney,Sevin;Tasci,TOnur;Atalar,Ergin
通讯作者：
Atalar,Ergin

MRI dynamic range and its compatibility with signal transmission media.