Innovative MRI Research Technology
创新的 MRI 研究技术
基本信息
- 批准号:6932391
- 负责人:
- 金额:$ 77.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-09-30 至 2008-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (Provided by Applicant): New advances in magnetic resonance imaging
(MRI) show enormous potential for a broad range ot new clinical and research
applications including high-speed cardiovascular imaging, functional brain
imaging, and contrast-sensitive image-guided intervention. They promise
important advances in the assessment and treatment of cardiovascular disease,
cancer and brain function. Central to their success are the dual demands of
imaging speed and signal-to-noise ratio (SNR). Core biotechnology research that
significantly advances MRJ speed and SNR are pivotal to progress and could
impact new MRI applications across-the-board. This proposal, responsive to
PAR-99-009 for Bioengineering Research, will directly advance MRI speed and SNR
with innovative research in fourkey areas: the MRI gradient systems; high-speed
multi-channel MRI receivers; new high-speed relaxation time (Ti) measurements
and imaging; and the design of MRI detector coil systems that deliver the
ultimate intrinsic SNR (UISNR)-the maximum that can be had. Specifically, we
propose to develop compact, highly-efficient surface MRI gradient modules that
can significantly increase gradient strength by more than an order of
magnitude, and reduce gradient rise-times, and to develop algorithms to correct
gradient nonlinearity. We will demonstrate the gradient advantages in a pilot
study of diffusion MRI in acutestroke. We will develop a high-speed
multi-channel receiver system with new analytic reconstruction methods for
sensitivity-encoding to achieve manifold reductions in the minimum scan-time,
and to realize the speed gains from the other projects, and we will demonstrate
this with real-time MRT stress-testing of patients with ischemia. Ti relaxation
is key to MRI contrast, and we propose new methods that promise dramatic
reductions in Ti measurement times, Ti imaging, and we will demonstrate its
potential for temperature monitoring during RF ablation therapy. andin human Ti
studies. Finally, we introduced the USINR concept, and will now develop tools
for designing coils that yield the UISNR, and build them for the head, heart,
and abdomen, and will compare their performance to existingcoils. We
hypothesize that the integration of radical redesigns of gradient, MRI detector
coils, and high-speed contrast-sensitive MRI, will yield simultaneous
performance gains that will provide truly new opportunities for clinical
diagnostic and interventional research. The work will be implemented at 1 .5T
and will directly and positively benefit 21 other funded research grants at
this institution, with broad potential benefit to noninvasive imaging in a wide
range of patients and diseases.
描述(由申请人提供):磁共振成像的新进展
项目成果
期刊论文数量(16)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Turning up the heat on MRI.
- DOI:10.1016/j.jacr.2008.04.003
- 发表时间:2008-07
- 期刊:
- 影响因子:4.5
- 作者:Bottomley, Paul A
- 通讯作者:Bottomley, Paul A
Measuring local RF heating in MRI: Simulating perfusion in a perfusionless phantom.
测量 MRI 中的局部射频加热:模拟无灌注模型中的灌注。
- DOI:10.1002/jmri.21161
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Akca,ImranB;Ferhanoglu,Onur;Yeung,ChristopherJ;Guney,Sevin;Tasci,TOnur;Atalar,Ergin
- 通讯作者:Atalar,Ergin
MRI dynamic range and its compatibility with signal transmission media.
- DOI:10.1016/j.jmr.2009.01.037
- 发表时间:2009-06
- 期刊:
- 影响因子:0
- 作者:Gabr RE;Schär M;Edelstein AD;Kraitchman DL;Bottomley PA;Edelstein WA
- 通讯作者:Edelstein WA
MRI Dynamic Range: Theory and Measurement.
MRI 动态范围:理论与测量。
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:Gabr,RE;Schar,M;Edelstein,AD;Bottomley,PA;Edelstein,WA
- 通讯作者:Edelstein,WA
A prototype RF dosimeter for independent measurement of the average specific absorption rate (SAR) during MRI.
原型射频剂量计,用于在 MRI 期间独立测量平均比吸收率 (SAR)。
- DOI:10.1002/jmri.21141
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Stralka,JohnP;Bottomley,PaulA
- 通讯作者:Bottomley,PaulA
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PAUL A BOTTOMLEY其他文献
PAUL A BOTTOMLEY的其他文献
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{{ truncateString('PAUL A BOTTOMLEY', 18)}}的其他基金
Direct MEG/EEG detection using a novel MRI approach
使用新型 MRI 方法进行直接 MEG/EEG 检测
- 批准号:
9566019 - 财政年份:2017
- 资助金额:
$ 77.45万 - 项目类别:
Advanced Intravascular MRI for Assessing Atherosclerosis
用于评估动脉粥样硬化的先进血管内 MRI
- 批准号:
8076898 - 财政年份:2008
- 资助金额:
$ 77.45万 - 项目类别:
Advanced MRI Technology in Safety & Intervention
先进的 MRI 安全技术
- 批准号:
7691733 - 财政年份:2008
- 资助金额:
$ 77.45万 - 项目类别:
Advanced MRI Technology in Safety & Intervention
先进的 MRI 安全技术
- 批准号:
8101079 - 财政年份:2008
- 资助金额:
$ 77.45万 - 项目类别:
Advanced Intravascular MRI for Assessing Atherosclerosis
用于评估动脉粥样硬化的先进血管内 MRI
- 批准号:
7658833 - 财政年份:2008
- 资助金额:
$ 77.45万 - 项目类别:
Advanced MRI Technology in Safety & Intervention
先进的 MRI 安全技术
- 批准号:
7886510 - 财政年份:2008
- 资助金额:
$ 77.45万 - 项目类别:
Advanced Intravascular MRI for Assessing Atherosclerosis
用于评估动脉粥样硬化的先进血管内 MRI
- 批准号:
7862316 - 财政年份:2008
- 资助金额:
$ 77.45万 - 项目类别:
Advanced MRI Technology in Safety & Intervention
先进的 MRI 安全技术
- 批准号:
7578096 - 财政年份:2008
- 资助金额:
$ 77.45万 - 项目类别: