Validity of DSM-IV ADHD Subtypes in a Community Sample

DSM-IV ADHD 亚型在社区样本中的有效性

• 批准号: 6797281
• 负责人: ERIK G WILLCUTT
• 金额: $ 33.93万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-10 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6797281
• 关键词: academic achievement; adolescence (12-20); attention deficit disorder; child (0-11); diagnosis quality /standard; functional ability; human subject; impulsive behavior; mental disorder diagnosis; neuropsychological tests; patient oriented research; statistics /biometry

DESCRIPTION (provided by applicant): The proposed project will test the internal and external validity of subtypes of DSM-IV ADHD using multiple converging methods. To accomplish these objectives, measures of ADHD symptoms, functional impairment, intellectual/academic achievement, other psychopathology, and neuropsychological functioning will be administered to the following groups selected from an initial pool of 11,000 non-referred children: 150 probands with the combined subtype, 150 with the hyperactive/impulsive subtype, 150 with the inattentive subtype who also exhibit significant symptoms of sluggish cognitive tempo (SCT), and 150 with the inattentive subtype without significant SCT symptoms, as well as comparison samples of 150 children with significant elevations of SCT who do not meet criteria for any ADHD subtype and 150 children without ADHD or significant SCT symptoms. Reliability and internal validity of the DSM-IV subtypes will be tested by examining inter-rater agreement and conducting exploratory and confirmatory factor and cluster analyses. Longitudinal follow-up measures will be obtained annually to facilitate analyses of the temporal stability and developmental course of the DSM-IV symptoms and subtypes. The diagnostic validity of the DSM-IV subtypes will be examined by testing if each subtype is associated with significant impairment in other domains of functioning. Discriminant validity among the subtypes will be evaluated by comparing subtypes on measures of functional impairment and other clinical correlates, and by testing if symptoms of SCT identify a diagnostically meaningful subset of individuals within the inattentive subtype. To examine both genetic and non-genetic etiological factors, pre/perinatal complications will be assessed and DNA samples will be obtained from all probands, their parents, and the biological sibling closest in age to the proband, facilitating a direct test for differential etiology of ADHD subtypes using genetic linkage and association analyses. Finally, all participants will complete an extensive battery of neurocognitive measures to test for differential performance among the subtypes on cognitive/attentional measures and the contribution of SOT to these differences. It is expected that the use of a large community sample, a longitudinal assessment, an etiologically informative design, and a broad battery of neurocognitive measures will provide important new information regarding the optimal nosology of ADHD.

描述(由申请人提供)：拟议的项目将测试 DSM-IV多动症亚型的内外效度研究 收敛方法。为了实现这些目标，ADHD症状的测量， 功能障碍、智力/学业成就、其他 精神病理学和神经心理功能将被用来 以下小组是从最初的11,000名未转介儿童中挑选出来的： 150名先证者合并亚型，150名多动/冲动先证者 亚型，150例注意力不集中的亚型也表现出明显的症状 认知节奏迟缓(SCT)，150例注意力不集中亚型 显著的SCT症状，以及150名儿童的对照样本 不符合任何ADHD亚型标准的SCT显著升高 150名无ADHD或明显SCT症状的儿童。可靠性和内部 DSM-IV亚型的有效性将通过检查评分者之间的关系来测试 同意并进行探索性和验证性因素和集群 分析。每年将采取纵向跟进措施，以 促进分析中国经济的时间稳定性和发展历程 DSM-IV症状和亚型。DSM-IV亚型的诊断效度 将通过测试每个子类型是否与显著相关进行检查 其他功能领域的损害。区分效度在不同性别间的差异 子类型将通过比较功能度量上的子类型来评估 损害和其他临床相关性，并通过测试SCT的症状 标识具有诊断意义的个体子集 注意力不集中的亚型。同时检查遗传和非遗传病因 因素，产前/围产期并发症将进行评估，DNA样本将 从所有先证者、他们的父母和亲生兄弟姐妹那里获得 在先证者的年龄上，便于直接测试鉴别病因学 应用遗传连锁和关联分析研究ADHD亚型。最后，所有 参与者将完成一系列广泛的神经认知测量以 认知/注意亚型间差异表现的测验 以及国营石油公司对这些差异的贡献。预计 使用大的社区样本，纵向评估，和 病因学信息设计，以及广泛的神经认知电池 测量将提供有关最佳病因学的重要新信息 多动症的症状。