Early diagnosis of meningitis using multiplex biomarker-based detection

使用基于多重生物标志物的检测对脑膜炎进行早期诊断

• 批准号: 2436987
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2436987
• 关键词: Early; diagnosis; meningitis; using; multiplex

Meningitis is the second largest infectious killer of children in the world. Meningitis is usually caused by a viral or a bacterial infection. Viral meningitis, the most common, is less serious; however, bacterial meningitis can lead to severe health problems if not treated. The symptoms presented by patients infected by bacterial meningitis are very similar to those of many illnesses, which hinders its detection. The current diagnostic test is time-consuming and requires of specialised laboratories, involving the examination of cerebrospinal fluid. This leads, in some cases, to the administration of antibiotics before confirmation of the infection. There is a need for the development of diagnostics tests for the early detection and discrimination of bacterial meningitis that are rapid, simple to perform and that can be deployed at the point-of-care. Addressing this challenge forms the basis of this project. The outcome of this project could set the basis for the development of point-of-care diagnostic tools for other infectious diseases and would limit unnecessary use of antibiotics.

脑膜炎是世界上儿童的第二大传染性杀手。脑膜炎通常由病毒或细菌感染引起。病毒性脑膜炎是最常见的，但不太严重;然而，细菌性脑膜炎如果不治疗，可能会导致严重的健康问题。感染细菌性脑膜炎的患者所呈现的症状与许多疾病的症状非常相似，这阻碍了其检测。目前的诊断测试耗时，需要专门的实验室，包括脑脊液检查。在某些情况下，这导致在确认感染之前给予抗生素。需要开发用于早期检测和区分细菌性脑膜炎的诊断测试，其快速、易于执行并且可以在护理点部署。应对这一挑战是本项目的基础。该项目的成果可以为其他传染病的即时诊断工具的开发奠定基础，并将限制抗生素的不必要使用。