Type 1 Resistant Starch: A journey through the gut

英国大多数成年人超重或肥胖，迫切需要更健康的加工食品。一种解决方案是用“抗性淀粉”代替饮食中的“可用淀粉”，抗性淀粉在上消化道不易消化为葡萄糖，因此进入结肠。豆类的可食用植物组织是1型抗性淀粉（RS 1）的天然来源，但RS 1的膳食摄入量从未有过系统的记录。此外，这些结构对食物加工和消化的适应性还没有很好的了解-这些结构如何逃脱上消化道的消化？进入结肠的消化食物的性质是什么？常驻微生物群是否能够分解这些抗性淀粉结构？在该项目中，分离的植物细胞将用于研究RS 1的消化命运及其对人类肠道微生物组的影响。

Most adults in the UK are overweight or obese, and healthier processed foods are urgently needed. One solution is to replace 'available starch' in the diet with 'resistant starch' that is not readily digested to glucose in the upper-gut, and therefore enters the colon. Edible plant-tissues from pulses are a natural source of Type 1 Resistant starch (RS1), but the dietary intake of RS1 has never been systematically documented. Furthermore, the resilience of these structures to food processing and digestion are not well understood - How do these structures escape digestion in the upper gut? What is the nature of the digested food material that enters the colon? Are the resident microbiota capable of disassembling these resistant starch structures?In this project isolated plant cells will be used to study the digestive fate of RS1 and its impact on the microbiome that resides in the human gut.