INFLAME: Inflammation and Exercise

描述（由申请人提供）：c反应蛋白（CRP）是一种全身性炎症的标志物，已被报道为女性和男性心血管疾病的独立预测因子。我们最近发表的横断面分析数据显示，CRP与心肺健康呈负相关，并且这种关联与体重指数无关。有规律的运动可能会影响CRP，这是评估降低CRP升高的一种干预措施。尽管有大量的研究集中在相关的主题上，但据我们所知，还没有发表过关于运动训练对CRP影响的随机临床试验的报告。这项名为炎症与运动（INFLAME）的研究的目的是确定运动训练对最初久坐不动的女性和男性（18至75岁）CRP浓度升高（等于或大于2.0 mg/L）的影响。我们将随机将170人平均分配到不运动的对照组和运动组。锻炼的人将每周参加3到4次训练，持续4个月，直到总能量消耗为16千卡。公斤(1)。每周（-1），这是目前公共卫生建议的运动剂量上限。目标运动强度为基线最大摄氧量的50-70%。主要结局指标是血浆CRP浓度。次要结果是变量的变化，这是定期运动可能降低CRP的潜在机制。这些指标包括内脏脂肪、细胞因子IL-6和tnf - α，以及作为自主神经平衡指标的心率变异性。这项研究的另一个优势是，虽然主要结果是CRP，但这项研究也将为研究运动对内脏脂肪、细胞因子和心率变异性变量的影响的有限文献做出重大贡献。

DESCRIPTION (provided by applicant): C-reactive protein (CRP), a marker of systemic inflammation, has been reported to be an independent predictor of cardiovascular disease in both women and men. We recently published data from cross-sectional analyses showing that CRP is inversely related to cardiorespiratory fitness, and that this association is independent of body mass index. The possibility that regular exercise may affect CRP presents an intervention to evaluate for reducing elevated CRP. Though there are a number of studies focusing on related topics, to our knowledge there are no published reports from randomized clinical trials on the effect of exercise training alone on CRP. The goal of the proposed study, Inflammation and Exercise (INFLAME), is to determine the effect of exercise training on elevated (equal to or greer than 2.0 mg/L) CRP concentrations in initially sedentary women and men (18 to 75 years old). We will randomly assign 170 individuals equally to a no exercise control group or to an exercise group. Exercising individuals will participate in 3 or 4 training sessions each week for 4 months progressing to a total energy expenditure of 16 kcal . kg(-1) . week(-1), which is an exercise dose at the upper end of current public health recommendations for physical activity. The target exercise intensity will be 50-70% of baseline VO2 max. The primary outcome measure is plasma CRP concentration. Secondary outcomes are changes in variables that are potential mechanisms whereby regular exercise might reduce CRP. These include visceral adiposity, the cytokines IL-6 and TNF-alpha, and heart rate variability as a measure of autonomic balance. An additional strength of this proposed study is that although the primary outcome is CRP, this study would also contribute significantly to the limited body of literature examining the effect of exercise on the variables of visceral adiposity, cytokines, and heart rate variability.