Health benefits of Aerobic and Resistance Training in individuals with Diabetes

描述（由申请人提供）：拟议研究的目标，有氧和阻力训练对2型糖尿病（HART-D）患者的健康益处，是在最初久坐的2型糖尿病（T2 D）女性和男性中，比较单独阻力训练和阻力与有氧训练相结合与单独有氧训练对血红蛋白A1 c（HbA 1c）的影响。虽然人们普遍认为，定期运动为T2 D患者提供了实质性的健康益处，但就类型（有氧运动与阻力运动与两者）而言，确切的运动处方仍在很大程度上未被探索，特别是在通过HbA 1c评估的每周血糖控制方面。例如，很少有研究检查阻力训练单独对糖尿病患者的益处，也没有足够的动力或对照试验检查阻力训练与有氧训练相结合的益处。这是特别有问题的，因为大多数来自国家组织的T2 D个体运动处方的建议/指南建议有氧和阻力训练的组合以获得最大的健康益处。有必要进行更多的研究，以帮助更好地制定T2 D患者的运动建议，并可能提供更多的运动选择，这是非常重要的，因为T2 D患者中经常参加运动的比例很小。研究组将是久坐的T2 D女性和男性，年龄在30至75岁之间。我们将300名受试者随机分为仅有氧运动训练组（AT）、仅阻力训练组（RT）或有氧运动加阻力训练组（AT+RT）。AT个体将每周参加3或4次训练，持续9个月，总能量消耗逐渐达到12千卡/千克/周（KKW），这是符合T2 D个体当前公共卫生体力活动建议的运动剂量。RT组每周将参加3次会议（每次30-45分钟），重点是大肌肉群。AT+RT组的个人将接受12 KKW的有氧训练和每周2次、每次20分钟的减阻训练方案。这种组合方案代表了美国运动医学学院和美国糖尿病协会的确切运动建议。简单地说，我们希望检查RT在降低HbA 1c方面是否具有与标准AT计划相当的益处，以及AT +RT的混合计划在降低HbA 1c方面是否上级AT单独（& RT单独）。主要结果指标是HbA 1c，这是过去8-12周血糖控制的综合指标。

DESCRIPTION (provided by applicant): The goal of the proposed study, Health benefits of Aerobic and Resistance Training in individuals with type 2 Diabetes (HART-D), is to compare the effect of resistance training alone, and resistance in combination with aerobic training to aerobic training alone on hemoglobin A1c (HbA1c), in initially sedentary women and men with type 2 diabetes (T2D). While it is generally accepted that regular exercise provides substantial health benefits to individuals with T2D, the exact exercise prescription in terms of type (aerobic versus resistance versus both) still remains largely unexplored, particularly in regard to week-to-week glucose control as assessed by HbA1c. For example, there has been very little research performed that examines the benefit of resistance training alone in individuals with diabetes, and there exists no adequately powered or controlled trials that have examined the benefits of combining resistance training with aerobic training. This is particularly problematic given that most recommendations/guidelines from national organizations for exercise prescription in individuals with T2D suggest a combination of aerobic and resistance training for maximal health benefits. There is a need for more research to help better formulate exercise recommendations for patients with T2D as well as potentially provide more exercise options, which is very important given the small percentage of individuals with T2D who regularly participate in exercise. The study group will be sedentary women and men with T2D, aged 30 to 75 years. We will randomly assign 300 individuals equally to an aerobic exercise training-only group (AT), a resistance training-only group (RT), or a combination of aerobic plus resistance training (AT+RT). The AT individuals will participate in 3 or 4 training sessions each week for 9 months, progressing to a total energy expenditure of 12 kcal/kg/week (KKW), which is an exercise dose consistent with the current public health recommendations for physical activity for individuals with T2D. The RT group will participate in 3 sessions per week (30-45 minutes each), which focus on large muscle groups. Individuals in the AT+RT group will receive both the 12 KKW of aerobic training and a reduced resistance-training regimen of 2 sessions per week at 20 minutes per session. This combination regimen represents the exact exercise recommendations of the American College of Sports Medicine and the American Diabetes Association. Simply stated, we wish to examine if a RT has comparable benefits in lowering HbA1c to a standard AT program, and if a hybrid program of AT +RT is superior to AT alone (& RT alone) in reducing HbA1c. The primary outcome measure is HbA1c, an integrated measure of blood glucose control over the past 8-12 weeks.