Nitrite and Nitric Oxide in Sickle Cell Blood

镰状细胞血中的亚硝酸盐和一氧化氮

基本信息

  • 批准号:
    6848917
  • 负责人:
  • 金额:
    $ 10.37万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2004
  • 资助国家:
    美国
  • 起止时间:
    2004-12-27 至 2009-11-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The candidate will have his teaching and service load reduced so that he can spend greater than 75% of his time on research. After earning a M.S. in physics, the candidate earned a Ph.D. in biophysics at UC Berkeley in 1993. He began studying sickle cell disease during his NIH-funded postdoctoral training. He has continued his focus on sickle cell disease since joining the Physics Department at Wake Forest University in 1996. Wake Forest University has about 3800 undergraduates, 600 graduate students, and 1,500 students in the professional schools of medicine, law, and business. The candidate currently has a spacious laboratory and office as a tenured Associate Professor of Physics. He is currently the principal investigator (PI) on a NIH-funded grant (R01 HL58091) focusing on the effects of nitric oxide (NO) in sickle cell blood. Patients with sickle cell anemia have been shown to have abnormal NO-related vasoactivity due to the scavenging of NO by cell-free hemoglobin. NO therapy may restore normal NO vasoactivity, and data has also recently been published suggesting that NO may upregulate fetal hemoglobin and thereby reduce sickling. The candidate is also a key collaborator on a study of the NO donating properties of hydroxyurea (an FDA approved drug for sickle cell disease). In addition, the candidate will expand his studies looking at the effects of NO in sickle cell blood by looking at the effects of nitrite as converted to NO by deoxygenated hemoglobin and thus serves as a reservoir for NO in the body. Finally, the candidate plans to develop non-invasive imaging tools to study pathology of the microcirculation in patients with sickle cell disease and the effects of therapeutics. The candidate currently has a heavy teaching and service load. A K02 award will relieve him of some of these duties so that he can spend more time interacting with his colleagues, attending seminars and meetings, and doing research.
描述(由申请人提供):

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

DANIEL B KIM-SHAPIRO其他文献

DANIEL B KIM-SHAPIRO的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('DANIEL B KIM-SHAPIRO', 18)}}的其他基金

Identification of bacterial strains for development of an oral probiotic aimed at increasing nitric oxide bioavailability
鉴定用于开发口服益生菌的菌株,旨在提高一氧化氮的生物利用度
  • 批准号:
    10666185
  • 财政年份:
    2023
  • 资助金额:
    $ 10.37万
  • 项目类别:
Nitric Oxide Donor Compounds for the Treatment of Hemolytic Conditions
用于治疗溶血病症的一氧化氮供体化合物
  • 批准号:
    7387531
  • 财政年份:
    2008
  • 资助金额:
    $ 10.37万
  • 项目类别:
Nitric Oxide Donor Compounds for the Treatment of Hemolytic Conditions
用于治疗溶血病症的一氧化氮供体化合物
  • 批准号:
    7554123
  • 财政年份:
    2008
  • 资助金额:
    $ 10.37万
  • 项目类别:
Nitrite and Nitric Oxide in Sickle Cell Blood
镰状细胞血中的亚硝酸盐和一氧化氮
  • 批准号:
    7166100
  • 财政年份:
    2004
  • 资助金额:
    $ 10.37万
  • 项目类别:
Nitrite and Nitric Oxide in Sickle Cell Blood
镰状细胞血中的亚硝酸盐和一氧化氮
  • 批准号:
    7328594
  • 财政年份:
    2004
  • 资助金额:
    $ 10.37万
  • 项目类别:
Nitrite and Nitric Oxide in Sickle Cell Blood
镰状细胞血中的亚硝酸盐和一氧化氮
  • 批准号:
    6999383
  • 财政年份:
    2004
  • 资助金额:
    $ 10.37万
  • 项目类别:
Nitrite and Nitric Oxide in Sickle Cell Blood
镰状细胞血中的亚硝酸盐和一氧化氮
  • 批准号:
    7536043
  • 财政年份:
    2004
  • 资助金额:
    $ 10.37万
  • 项目类别:
STOPPED-FLOW OPTICAL ROTATARY DISPERSION SPECTROMETER
停流光学旋转色散光谱仪
  • 批准号:
    6016628
  • 财政年份:
    1999
  • 资助金额:
    $ 10.37万
  • 项目类别:
MECHANISM AND KINETICS OF SICKLE CELL HEMOGLOBIN
镰状细胞血红蛋白的机制和动力学
  • 批准号:
    2456404
  • 财政年份:
    1998
  • 资助金额:
    $ 10.37万
  • 项目类别:
Effects of Nitric Oxide in Sickle Cell Blood
一氧化氮对镰状细胞血的影响
  • 批准号:
    8658135
  • 财政年份:
    1998
  • 资助金额:
    $ 10.37万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了