Effects of Drug Use and Cessation on Monkey Brain

吸毒和戒烟对猴脑的影响

• 批准号: 6831517
• 负责人: ITAMAR RONEN
• 金额: $ 14.57万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6831517
• 关键词: Macaca mulatta; behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; cocaine; drug /alcohol abstinence; drug abuse; longitudinal animal study; magnetic resonance imaging; method development; neuroanatomy; neurochemistry; neuropharmacology; neurophysiology; restraint; self medication

DESCRIPTION (provided by applicant): Human studies show that cocaine dependence affects the microstructure of white matter, probably as a result of vasoconstrictive effects of the drug. Little is known, however, about the temporal development of the white matter injury and the changes in cerebral vasculature during the dependence period, or about the recovery of both with cessation of the drug use. Magnetic resonance imaging (MRI) provides tools that are highly suitable for investigating in a non-invasive manner the anatomical, structural and functional and chemical characteristics of the brain. In this application we propose to implement a set of MRI techniques for investigating the effects of the use of cocaine on monkey brain, in particular its effects on white matter microstructure on gray/white matter volumes, on the vascularity and perfusion of gray and white matter and on the neurochemical profile of the monkey brain. These techniques will be used to perform a preliminary study on a small and well-controlled population of monkeys. Aim 1. To develop a robust methodology for investigating structural, anatomical and functional measures in monkey brains. Aim 2. To collect preliminary data on the effects of drug use and its cessation on monkey brain. We hypothesize that: 1. Long term cocaine self-administration will result in brain changes in the monkeys similar to those seen in human studies. 2. Cessation of drug use will result in a normalization of brain measures. This will address the important issue of whether or not there is significant brain recovery following cessation of drug use.

描述（由申请人提供）：人体研究表明，可卡因依赖性影响白色物质的微观结构，可能是由于药物的血管收缩作用。然而，关于依赖期间白色物质损伤的时间发展和脑血管系统的变化，或者关于停止使用药物后两者的恢复，知之甚少。磁共振成像（MRI）提供了非常适合以非侵入性方式研究大脑的解剖学、结构和功能以及化学特征的工具。在本申请中，我们建议实施一套MRI技术，用于研究使用可卡因对猴脑的影响，特别是其对灰/白色物质体积上的白色物质微结构、对灰色和白色物质的血管分布和灌注以及对猴脑的神经化学特征的影响。这些技术将用于对一个小的、控制良好的猴群体进行初步研究。目标1。开发一种用于研究猴脑结构、解剖学和功能测量的稳健方法。目标二。收集关于药物使用和停止对猴脑影响的初步数据。我们假设：1.长期可卡因自我给药将导致猴子的大脑变化，类似于人类研究中观察到的变化。2.停止使用毒品将导致大脑测量正常化。这将解决一个重要问题，即停止使用毒品后大脑是否有明显的恢复。