WATER DIFFUSION IN CAT BRAIN MEASURED WITH A COMBINED MTC-DWI APPROACH: TOWARDS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 在这项研究中，水在猫脑扩散进行了研究，使用的方法，结合多个b值的多方向扩散加权图像（DWI），连同磁化传递对比（MTC）。 MTC允许衰减源自与大的大分子结构上的结合位点快速交换的水分子的信号，并且在脑白色物质中，假设MTC的显著部分是由于水与轴突外髓鞘的相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, water diffusion in the cat brain was investigated using an approach that combines multidirectional diffusion weighted images (DWI) using multiple b-values, together with magnetization transfer contrast (MTC). The MTC allows attenuate signal originating from water molecules that rapidly exchange with binding sites on large macromolecular structures, and in brain white matter it is assumed that a significant portion of the MTC is due to the interaction of water with the extraaxonal myelin sheath.