WATER DIFFUSION IN CAT BRAIN MEASURED WITH A COMBINED MTC-DWI APPROACH: TOWARDS

使用 MTC-DWI 组合方法测量猫脑中的水扩散：朝向

• 批准号: 7721348
• 负责人: ITAMAR RONEN
• 金额: $ 1.78万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721348
• 关键词: Attenuated; Binding Sites; Brain; Computer Retrieval of Information on Scientific Projects Database; Diffusion weighted imaging; Felis catus; Funding; Grant; Institution; Measures; Molecular Structure; Myelin Sheath; Research; Research Personnel; Resources; Signal Transduction; Source; United States National Institutes of Health; Water; water diffusion; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, water diffusion in the cat brain was investigated using an approach that combines multidirectional diffusion weighted images (DWI) using multiple b-values, together with magnetization transfer contrast (MTC). The MTC allows attenuate signal originating from water molecules that rapidly exchange with binding sites on large macromolecular structures, and in brain white matter it is assumed that a significant portion of the MTC is due to the interaction of water with the extraaxonal myelin sheath.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在这项研究中，水在猫脑扩散进行了研究，使用的方法，结合多个b值的多方向扩散加权图像（DWI），连同磁化传递对比（MTC）。 MTC允许衰减源自与大的大分子结构上的结合位点快速交换的水分子的信号，并且在脑白色物质中，假设MTC的显著部分是由于水与轴突外髓鞘的相互作用。