WATER DIFFUSION IN CAT BRAIN MEASURED WITH A COMBINED MTC-DWI APPROACH: TOWARDS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在这项研究中，使用多个b值的多方向扩散加权图像(DWI)和磁化传递对比度(MTC)相结合的方法来研究猫脑中的水扩散。MTC允许衰减来自水分子的信号，这些水分子与大分子结构上的结合部位快速交换，在脑白质中，MTC的很大一部分被认为是由于水与轴突外髓鞘的相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, water diffusion in the cat brain was investigated using an approach that combines multidirectional diffusion weighted images (DWI) using multiple b-values, together with magnetization transfer contrast (MTC). The MTC allows attenuate signal originating from water molecules that rapidly exchange with binding sites on large macromolecular structures, and in brain white matter it is assumed that a significant portion of the MTC is due to the interaction of water with the extraaxonal myelin sheath.