WATER DIFFUSION IN CAT BRAIN MEASURED WITH A COMBINED MTC-DWI APPROACH: TOWARDS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, water diffusion in the cat brain was investigated using an approach that combines multidirectional diffusion weighted images (DWI) using multiple b-values, together with magnetization transfer contrast (MTC). The MTC allows attenuate signal originating from water molecules that rapidly exchange with binding sites on large macromolecular structures, and in brain white matter it is assumed that a significant portion of the MTC is due to the interaction of water with the extraaxonal myelin sheath.