LCP Nerve Cuff with Telemetry for Prosthetic Sensation

带遥测功能的 LCP 神经袖带用于假肢感觉

• 批准号: 6833002
• 负责人: RONALD Raymond RISO
• 金额: $ 18.38万
• 依托单位: INNERSEA TECHNOLOGY, INC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2006-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6833002
• 关键词: afferent nerve; amputation; bioengineering /biomedical engineering; biomedical equipment development; clinical biomedical equipment; electrodes; electronic stimulator; electrostimulus; iridium; liquid crystal; nervous system prosthesis; polymers; portable biomedical equipment; sensation; telemetry

DESCRIPTION (provided by applicant): This project seeks to develop a multi-channel nerve cuff with on board wireless control for stimulating specific bundles of fibers within trunk nerves. Clinical applications include: 1) Stimulating the sensory nerves in the residual limbs of amputees to provide touch sensations from their prosthetic arms. By activating specific components of the median nerve, it will be possible to induce sensations that appear to the amputee to emanate from specific regions of the fingers and hand. By providing input from each of the contacting fingers at the same time, a prosthesis user will be able to know which fingers are in contact with a grasp object and how the forces are distributed. Additionally, electrical activation of amputated sensory nerves has been demonstrated to allow amputees to consider their prosthesis to be more a part of their body, and such electrical stimulation has been shown to be useful for preventing or managing phantom limb pain. 2) Muscle stimulation systems that restore hand function or standing and walking in cases of spinal cord injury and stroke. The use of multi-channel cuffs that don't require attached lead wires can reduce the surgery needed to implant stimulation hardware and eliminate the need to implant separate electrodes into each muscle in these systems, and it will offer improved muscle controllability. 3) The multi-channel cuff would also be useful for optic nerve stimulation for artificial vision. The cuff that will be developed uses a self-coiling design made from thin silicone sheeting laminated around a separate lattice structure containing the electrode contacts and interconnect traces. The lattice is made from Liquid Crystal Polymer sheeting (LCP) which has ideal properties for implanted electronic devices: including low tissue reactivity; high resistance to stretching, tearing and breakage from repeated bending; and the ability to be micro-machined to form arbitrary patterns. Electronic components and interconnects are easily mounted on LCP, and a vapor tight package can be formed by welding an LCP 'cap' to the substrate. This packaging advantage of using LCP enables the stimulation and wire-less control circuitry to be located directly on the cuff. The PHASE 1 project includes initial bench testing of the cuffs and the integral electronics and packaging methods. PHASE II work will involve in-vivo tests in animal models followed by evaluation in clinical trials with amputee volunteers and with spinal cord injury and stroke patients.

描述(申请人提供)：这个项目寻求开发一种多通道神经袖带，带有机载无线控制，用于刺激躯干神经中特定的纤维束。临床应用包括：1)刺激截肢者残肢的感觉神经，以提供假肢的触觉。通过激活正中神经的特定组成部分，将有可能诱导截肢者似乎从手指和手的特定区域发出的感觉。通过同时提供来自每个接触手指的输入，假肢使用者将能够知道哪些手指与抓取对象接触以及力是如何分布的。此外，截肢感觉神经的电激活已被证明允许截肢者认为他们的假肢更多地是他们身体的一部分，这种电刺激已被证明对预防或管理幻肢疼痛有用。2)肌肉 在脊髓损伤和中风的情况下恢复手功能或站立和行走的刺激系统。使用不需要连接导线的多通道袖带可以减少植入刺激硬件所需的手术，并消除在这些系统的每一块肌肉中植入单独电极的需要，并且它将提供更好的肌肉可控性。3)多通道袖带也可用于人工视觉的视神经刺激。将开发的袖带使用自卷式设计，由薄薄的硅胶片层叠在包含电极触点和互连痕迹的单独格子结构周围。晶格由液晶聚合物薄片(LCP)制成，具有植入式电子设备的理想特性：包括低组织反应性；高抗拉伸、抗反复弯曲撕裂和断裂；以及能够进行微机械加工以形成任意图案。 电子元器件和互连很容易安装在LCP上，通过将LCP‘帽’焊接到基板上可以形成不透气的封装。使用LCP的这种封装优势使刺激和无线控制电路能够直接位于袖带上。第一阶段的项目包括对袖带以及集成电子和封装方法进行初步的台架测试。第二阶段的工作将包括在动物模型中进行体内测试，然后在截肢志愿者以及脊髓损伤和中风患者的临床试验中进行评估。