Gridless Simulation of Flow-MPHV Interaction

流动与 MPHV 相互作用的无网格仿真

• 批准号: 6832970
• 负责人: ADRIN GHARAKHANI
• 金额: $ 10万
• 依托单位: APPLIED SCIENTIFIC RESEARCH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6832970
• 关键词: bioengineering /biomedical engineering; computer program /software; computer simulation; computer system design /evaluation; fluid flow; fluidity; medical implant science; molecular dynamics; prosthetic heart valve

DESCRIPTION (provided by applicant): The objective of this project is to develop a grid-free CFD software for the simulation and analysis of the complex dynamics of the Fluid-Structure Interaction (FSI) associated with Mechanical Prosthetic Heart Valve (MPHV) "systems" as they respond to physiologically realistic 3-D pulsatile flow, which includes laminar and turbulent flow regimes as well as transition between the two regimes. The final product will be the first commercially available grid-free "virtual MPHV test chamber", which can be used by scientists and heart valve designers, for example, to investigate new hypotheses on the hemodynamic aspect of cardiac physiology; to perform parametric studies in order to design new or to improve existing prosthetic valves; or to establish criteria for MPHV implantation (e.g. orientation) under which valve performance will be acceptable. The research aims specifically at (1) coupling an existing MPI-parallel, fast Lagrangian vortex element method with a structural dynamics code, and (2) validating the resultant software using physiologically realistic test cases.

描述（由申请人提供）： 本项目的目标是开发一个无网格CFD软件，用于模拟和分析与机械人工心脏瓣膜（MPHV）“系统”相关的流体-结构相互作用（FSI）的复杂动力学，因为它们响应于生理上真实的3-D脉动流，包括层流和湍流状态以及两种状态之间的过渡。最终产品将是第一个商业上可用的无网格“虚拟MPHV试验室”，可供科学家和心脏瓣膜设计者使用，例如，研究心脏生理学血液动力学方面的新假设;进行参数研究，以设计新的或改进现有的人工瓣膜;或建立MPHV植入标准（例如定向），在此标准下瓣膜性能可接受。该研究的具体目的是（1）耦合现有的MPI并行，快速拉格朗日涡元方法与结构动力学代码，和（2）验证所得的软件使用生理现实的测试用例。

项目成果

Isolation, quantitation, and characterization of a stable complex formed by Lp[a] binding to triglyceride-rich lipoproteins.

Lp[a] 与富含甘油三酯的脂蛋白结合形成的稳定复合物的分离、定量和表征。

• 发表时间: 2001
• 期刊: Journal of lipid research
• 影响因子: 6.5
• 作者: Gaubatz,JW;Hoogeveen,RC;Hoffman,AS;Ghazzaly,KG;Pownall,HJ;GuevaraJr,J;Koschinsky,ML;Morrisett,JD
• 通讯作者: Morrisett,JD