A Meshless Two-Phase Platelet Transport Model For MPHVs

MPHV 的无网格两相血小板传输模型

• 批准号: 6991811
• 负责人: ADRIN GHARAKHANI
• 金额: $ 16.34万
• 依托单位: APPLIED SCIENTIFIC RESEARCH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-23 至 2007-03-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6991811
• 关键词: hemodynamics; mathematical model; medical implant science; model design /development; platelets; prosthetic heart valve

DESCRIPTION (provided by applicant): The overall objective of this project is to develop computational models for investigating flow induced platelet dynamics around and downstream of Mechanical Prosthetic Heart Valves (MPHVs). The underlying justification for the need for such a tool is the common understanding that current valve designs generate flows that are characterized by high shear stresses, turbulent fluctuations, and regions of blood recirculation, which in turn enhance the risk of thrombus formation by inducing platelet activation, and subsequent aggregation and deposition downstream of the valve. The aim is to develop a particulate-laden two-phase flow model of blood with two-way coupling, to incorporate the latter into an existing 3-D massively-parallel CFD software for grid-free simulation of unsteady laminar-turbulent incompressible flow, and to investigate the robustness of the developed technology using a set of benchmark tests. The specific aims of Phase I are (1) to implement and test a generic meshless two-phase flow solver with two-way coupling, and (2) to formulate specific models and boundary conditions that pertain to platelet dynamics, which can then be implemented and tested during Phase II.

描述（由申请人提供）：该项目的总体目标是开发用于研究机械假心脏瓣膜（mphv）周围和下游血流诱导血小板动力学的计算模型。需要这种工具的基本理由是，人们普遍认为，目前的瓣膜设计产生的血流具有高剪切应力、湍流波动和血液再循环区域的特征，这反过来又通过诱导血小板活化以及随后在瓣膜下游的聚集和沉积增加了血栓形成的风险。目的是建立一种双向耦合的含颗粒两相血液流动模型，并将其整合到现有的三维大规模并行CFD软件中，用于非定常层流不可压缩流动的无网格模拟，并通过一组基准测试来研究所开发技术的鲁棒性。第一阶段的具体目标是：(1)实现和测试具有双向耦合的通用无网格两相流求解器，(2)制定与血小板动力学相关的特定模型和边界条件，然后可以在第二阶段实现和测试。