A Meshless Two-Phase Platelet Transport Model For MPHVs

MPHV 的无网格两相血小板传输模型

• 批准号: 6991811
• 负责人: ADRIN GHARAKHANI
• 金额: $ 16.34万
• 依托单位: APPLIED SCIENTIFIC RESEARCH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-23 至 2007-03-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6991811
• 关键词: hemodynamics; mathematical model; medical implant science; model design /development; platelets; prosthetic heart valve

DESCRIPTION (provided by applicant): The overall objective of this project is to develop computational models for investigating flow induced platelet dynamics around and downstream of Mechanical Prosthetic Heart Valves (MPHVs). The underlying justification for the need for such a tool is the common understanding that current valve designs generate flows that are characterized by high shear stresses, turbulent fluctuations, and regions of blood recirculation, which in turn enhance the risk of thrombus formation by inducing platelet activation, and subsequent aggregation and deposition downstream of the valve. The aim is to develop a particulate-laden two-phase flow model of blood with two-way coupling, to incorporate the latter into an existing 3-D massively-parallel CFD software for grid-free simulation of unsteady laminar-turbulent incompressible flow, and to investigate the robustness of the developed technology using a set of benchmark tests. The specific aims of Phase I are (1) to implement and test a generic meshless two-phase flow solver with two-way coupling, and (2) to formulate specific models and boundary conditions that pertain to platelet dynamics, which can then be implemented and tested during Phase II.

描述（由申请人提供）：本项目的总体目标是开发用于研究机械人工心脏瓣膜（MPHV）周围和下游的流动诱导血小板动力学的计算模型。需要这种工具的基本理由是普遍理解，当前的瓣膜设计产生的流动的特征在于高剪切应力、湍流波动和血液再循环区域，这反过来又通过诱导血小板活化以及随后的聚集和瓣膜下游的沉积而增加血栓形成的风险。其目的是开发一个颗粒负载的两相流模型的血液与双向耦合，将后者纳入现有的3-D并行计算流体动力学软件的非定常层流湍流不可压缩流的无网格模拟，并调查的鲁棒性的开发技术使用一组基准测试。第一阶段的具体目标是（1）实现和测试具有双向耦合的通用无网格两相流求解器，以及（2）制定与血小板动力学有关的特定模型和边界条件，然后可以在第二阶段期间实现和测试。