Gridless Simulation of Flow-MPHV Interaction

流动与 MPHV 相互作用的无网格仿真

• 批准号: 7220689
• 负责人: ADRIN GHARAKHANI
• 金额: $ 45.64万
• 依托单位: APPLIED SCIENTIFIC RESEARCH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7220689
• 关键词: 3-Dimensional; Accounting; Address; Affect; Algorithms; Aorta; Beauty; Benchmarking; Bioprosthesis device; Blood; Blood Clot; Blood Vessels; Blood coagulation; Cardiac; Categories; Cause of Death; Classification; Client; Coagulants; Code; Complex; Complication; Computational Technique; Computer software; Condition; Coupled; Coupling; Data; Development; Disease; Economics; Elements; Embolism; Equation; Evaluation; Family; Feedback; Future; Growth; Health; Heart; Heart Valve Prosthesis; Heart Valves; Hemolysis; Image; Indium; Laboratories; Lead; Left ventricular structure; Life; Liquid substance; Maps; Mechanics; Medical; Memory; Methods; Mitral Valve; Modeling; Motion; Numbers; Operative Surgical Procedures; Patients; Performance; Phase; Physiology; Positioning Attribute; Postoperative Complications; Process; Prosthesis; Pulsatile Flow; Purpose; Quality Control; Quality of life; Range; Rate; Research; Resolution; Resources; Rest; Rotation; Saint Jude Children' s Research Hospital; Scientist; Senior Scientist; Shapes; Simulate; Solid; Solutions; Source; Specific qualifier value; Speed; Standards of Weights and Measures; Stroke; Structure; Surface; System; Technology; Testing; Thick; Thromboembolism; Thrombus; Time; Velocimetries; Weight; aortic valve; base; biomaterial compatibility; commercialization; computer studies; design; experience; falls; hemodynamics; implantation; improved; object shape; particle; prevent; prototype; research and development; response; simulation; size; software development; success; time use; vascular factor; virtual

DESCRIPTION (provided by applicant): The objective of this project is to develop a CFD software for the grid-free simulation and analysis of the complex dynamics of the Fluid-Structure Interaction (FSI) associated with Mechanical Prosthetic Heart Valve (MPHV) "systems" as they respond to physiologically realistic 3-D pulsatile flow. The final product will be the first commercially available grid-free "virtual MPHV test chamber," which can be used by scientists and heart valve designers, for example, to investigate new hypotheses on the unsteady hemodynamic aspect of cardiac physiology; to perform parametric studies in order to design new or to improve existing prosthetic valves; or to establish criteria for MPHV implantation (e.g. orientation) under which valve performance will be acceptable. The specific research aims are to (1) develop accurate methods for fluid force calculations on the valves and implement the coupling between the fluid and the valve; (2) implement computational techniques to further improve adaptivity, user friendliness and CPU turn around times; and (3) validate the resultant software using physiologically realistic test cases.

描述（由申请人提供）：本项目的目的是开发一种CFD软件，用于无网格模拟和分析与机械人工心脏瓣膜（MPHV）“系统”相关的流体-结构相互作用（FSI）的复杂动力学，因为它们响应生理上真实的3-D脉动流。最终产品将是第一个商业上可用的无网格“虚拟MPHV试验室”，可供科学家和心脏瓣膜设计者使用，例如，研究心脏生理学不稳定血液动力学方面的新假设;进行参数研究，以设计新的或改进现有的人工瓣膜;或建立MPHV植入标准（例如定向），在此标准下瓣膜性能可接受。具体的研究目标是：（1）开发精确的阀门流体力计算方法，并实现流体和阀门之间的耦合;（2）实施计算技术，以进一步提高自适应性，用户友好性和CPU周转时间;（3）使用生理上真实的测试用例验证所得软件。