Gridless Simulation of Flow-MPHV Interaction

描述(申请人提供)：该项目的目标是开发一种CFD软件，用于无网格模拟和分析与机械假体心脏瓣膜(MPHV)“系统”相关的流体-结构相互作用(FSI)的复杂动力学，因为它们响应生理上真实的3-D脉动流。最终产品将是第一个商业化的无网格“虚拟MPHV测试室”，科学家和心脏瓣膜设计者可以使用它来研究心脏生理学的非稳定血流动力学方面的新假设；进行参数研究以设计新的或改进现有的人工瓣膜；或建立MPHV植入的标准(例如，定位)，在该标准下瓣膜性能将是可接受的。具体的研究目标是(1)开发精确的阀门流体力计算方法，并实现流体与阀门之间的耦合；(2)实施计算技术，以进一步提高适应性、用户友好性和CPU周转时间；以及(3)使用生理上真实的测试案例验证生成的软件。

DESCRIPTION (provided by applicant): The objective of this project is to develop a CFD software for the grid-free simulation and analysis of the complex dynamics of the Fluid-Structure Interaction (FSI) associated with Mechanical Prosthetic Heart Valve (MPHV) "systems" as they respond to physiologically realistic 3-D pulsatile flow. The final product will be the first commercially available grid-free "virtual MPHV test chamber," which can be used by scientists and heart valve designers, for example, to investigate new hypotheses on the unsteady hemodynamic aspect of cardiac physiology; to perform parametric studies in order to design new or to improve existing prosthetic valves; or to establish criteria for MPHV implantation (e.g. orientation) under which valve performance will be acceptable. The specific research aims are to (1) develop accurate methods for fluid force calculations on the valves and implement the coupling between the fluid and the valve; (2) implement computational techniques to further improve adaptivity, user friendliness and CPU turn around times; and (3) validate the resultant software using physiologically realistic test cases.