Airborne Nanoparticles for Therapeutic Applications

描述（由申请人提供）：提出了一种以微克/分钟的速率产生尺寸范围为20-100 nm的空气悬浮颗粒的装置。该粒子发生器将利用多喷头电喷雾的多个头部来获得所需的颗粒物质的吞吐量。提议的纳米粒子发生器将用于向动物模型输送某些强效药物。第一组动物实验将包括通过吸入将药物纳米颗粒输送到肺部。将研究颗粒沉积在动物肺不同部位的效率，并检查候选药物治疗腺癌（深肺癌）的功效。在第二组动物实验中，药物纳米颗粒将悬浮在全氟碳气体泡中，用于封堵和填塞视网膜裂口和裂口。本申请中的药物组合物旨在抑制增生性玻璃体视网膜病变（在疤痕组织存在下视网膜再脱离）。将设计试验来研究药物在这方面的功效。所提出的技术在产生空气悬浮大分子的有效性将被检查。我们还将研究将上述设备的吞吐量扩大到每分钟毫克的可行性。

DESCRIPTION (provided by applicant): A device for generating airborne particles in the size range 20-100 nm at the rate of micrograms per minute is proposed. This particle generator will utilize multiple heads of multi-jet electrosprays to obtain the desired throughput of the particulate matter. The proposed nanoparticle generator will be used to deliver certain potent drugs to animal models. The first set of animal experiments will involve delivery of drug nanoparticles to the lungs through inhalation. Particle deposition efficiencies in various parts of the animal lungs will be studied and efficacy of the candidate drugs in treating adenocarcinomas (cancer of the deep lung) will be examined. In a second set of animal experiments, the drug nanoparticles will be suspended in a perfluorocarbon gas bubble used to occlude and tamponade retinal breaks and tears. The drug composition in this application is intended to inhibit the proliferative vitreoratinopathy (re-detachment of the retina in the presence of a scar tissue). Tests will be designed to study the efficacy of the drugs in this respect. Effectiveness of the proposed technique in generating airborne suspensions of macromolecules will be examined. We will also study the feasibility of scaling up the throughput of the above device to milligrams per minute.