Airborne Nanoparticles for Therapeutic Applications

用于治疗应用的气载纳米颗粒

• 批准号: 6915126
• 负责人: AMIR A NAQWI
• 金额: $ 20万
• 依托单位: POWERSCOPE, INC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6915126
• 关键词: adenocarcinoma; biomedical equipment; biomedical equipment development; drug delivery systems; electric field; electrical conductance; fluidity; high throughput technology; inhalation drug administration; laboratory mouse; laboratory rabbit; lung neoplasms; molecular size; nanotechnology; neoplasm /cancer chemotherapy; particle accelerators; proliferative vitreoretinopathy; respiratory therapy; retina detachment; surface property

DESCRIPTION (provided by applicant): A device for generating airborne particles in the size range 20-100 nm at the rate of micrograms per minute is proposed. This particle generator will utilize multiple heads of multi-jet electrosprays to obtain the desired throughput of the particulate matter. The proposed nanoparticle generator will be used to deliver certain potent drugs to animal models. The first set of animal experiments will involve delivery of drug nanoparticles to the lungs through inhalation. Particle deposition efficiencies in various parts of the animal lungs will be studied and efficacy of the candidate drugs in treating adenocarcinomas (cancer of the deep lung) will be examined. In a second set of animal experiments, the drug nanoparticles will be suspended in a perfluorocarbon gas bubble used to occlude and tamponade retinal breaks and tears. The drug composition in this application is intended to inhibit the proliferative vitreoratinopathy (re-detachment of the retina in the presence of a scar tissue). Tests will be designed to study the efficacy of the drugs in this respect. Effectiveness of the proposed technique in generating airborne suspensions of macromolecules will be examined. We will also study the feasibility of scaling up the throughput of the above device to milligrams per minute.

描述（由申请人提供）：提出了一种用于以微克/分钟的速率产生尺寸范围为20-100 nm的气载颗粒的装置。该颗粒发生器将利用多射流电喷雾的多个头部来获得颗粒物质的期望吞吐量。所提出的纳米颗粒发生器将用于向动物模型提供某些有效的药物。第一组动物实验将涉及通过吸入将药物纳米颗粒输送到肺部。将研究动物肺的各个部分中的颗粒沉积效率，并将检查候选药物在治疗腺癌（肺深部的癌症）中的功效。在第二组动物实验中，药物纳米颗粒将悬浮在用于阻塞和填塞视网膜裂孔和撕裂的全氟化碳气泡中。本申请中的药物组合物旨在抑制增殖性玻璃体视网膜病变（在瘢痕组织存在下视网膜再脱离）。将设计测试来研究药物在这方面的功效。将检查所提出的技术在产生大分子的空气悬浮液的有效性。我们亦会研究把上述仪器的处理量提升至每分钟毫克的可行性。