Prenatal organochlorines, thyroid, and development

产前有机氯、甲状腺和发育

• 批准号: 6953779
• 负责人: Pam R Factor-Litvak
• 金额: $ 38.19万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6953779
• 关键词: adolescence (12-20); blood chemistry; child (0-11); child physical development; child psychology; chlorohydrocarbon insecticide; clinical research; cognition disorders; data collection methodology /evaluation; developmental disease /disorder; embryo /fetus toxicology; environmental exposure; gas chromatography; human pregnant subject; human subject; insecticide biological effect; interview; longitudinal human study; neuropsychological tests; outcomes research; postnatal growth disorder; pregnancy disorder; radioimmunoassay; thyroid disorder; women' s health

DESCRIPTION (provided by applicant): The overall goal of this project is to assess whether exposure to endocrine disrupting compounds during pregnancy is associated with a) adverse development (cognitive function, height, weight, weight for height, and for females, age at menarche) in the offspring at birth, early childhood, middle childhood, and adolescence, b) mild deficiencies in maternal thyroid function, and c) whether adverse developmental findings, if any, are attributed in part to deficiencies in exposure to maternal thyroid hormone in utero. The proposed study draws on data from the Child Health and Development Study, a longitudinal follow up of children born between 1959 and 1966 to mothers enrolled in the Oakland, California membership of the Kaiser Foundation Health Plan. Prenatal sera has been appropriately frozen and stored, and are available to assess both exposure to organochlorine compounds and maternal thyroid function during pregnancy. Serial measures of growth are available in the same children from birth to age 17 years, as are standardized developmental examinations at ages 5, 9-11, and 15-17. The proposed measures of organochlorine exposure and exposure to measures of maternal thyroid function (thyroid stimulating hormone, free thyroxine, thyroid peroxidase antibodies and transthyretin - a protein responsible for the transport of thyroid hormone). Statistical analyses will estimate associations taking advantage of the repeated measures structure of the data. The analyses will employ generalized estimating equations (GEE) methods for repeated measures, taking account of potentially confounding variables. We will distinguish effects of prenatal organochlorine exposures from infancy through adolescence. We will also investigate a specific mechanism: via maternal thyroid function. Results will fully describe the effects of prenatal exposure and will also further knowledge about the relation between subclinical maternal thyroid hormone deficiency and childhood development. This line of research could lead to prenatal interventions.

描述（由申请人提供）：该项目的总体目标是评估怀孕期间接触内分泌干扰化合物是否与 a) 后代出生时、幼儿期、中期和青春期的不良发育（认知功能、身高、体重、身高体重和女性初潮年龄）有关，b) 母亲甲状腺功能的轻度缺陷，以及 c) 是否会出现不良发育发现，如果 任何，部分归因于子宫内母体甲状腺激素暴露不足。 拟议的研究借鉴了儿童健康与发展研究的数据，该研究是对 1959 年至 1966 年间出生的儿童进行的纵向随访，这些儿童的母亲是加入凯撒基金会健康计划的加利福尼亚州奥克兰会员。产前血清已适当冷冻和储存，可用于评估怀孕期间有机氯化合物的暴露和母体甲状腺功能。对同一儿童从出生到 17 岁的一系列生长测量以及 5 岁、9-11 岁和 15-17 岁的标准化发育检查都可以进行。拟议的有机氯暴露测量和母体甲状腺功能暴露测量（促甲状腺激素、游离甲状腺素、甲状腺过氧化物酶抗体和运甲状腺素蛋白 - 一种负责甲状腺激素转运的蛋白质）。统计分析将利用数据的重复测量结构来估计关联性。分析将采用广义估计方程（GEE）方法进行重复测量，并考虑潜在的混杂变量。 我们将区分从婴儿期到青春期的产前有机氯暴露的影响。我们还将研究一种具体机制：通过母体甲状腺功能。结果将充分描述产前暴露的影响，并将进一步了解亚临床母亲甲状腺激素缺乏与儿童发育之间的关系。这一系列研究可能会导致产前干预。