Stereoselective nucleoside fluorination methodology for the development of next-generation oligonucleotide therapeutics

用于开发下一代寡核苷酸疗法的立体选择性核苷氟化方法

• 批准号: 2442011
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2442011
• 关键词: Stereoselective; nucleoside; fluorination; methodology; development

This project aims to develop new methodology to install fluorinated groups at defined positions within the ribose sugar of nucleosides. After synthesis of these modified nucleosides, they will then be incorporated into an oligonucleotide. Subsequently, these oligonucleotides will be screened for their Pharmacokinetic/pharmacodynamic properties, such as affinity and selectivity to a target RNA sequence, metabolic stability and cell uptake.

本项目旨在开发新的方法，在核苷的核糖糖内的特定位置安装氟化基团。在这些修饰的核苷合成后，它们将被整合到一个寡核苷酸中。随后，将筛选这些寡核苷酸的药代动力学/药效学特性，如对靶RNA序列的亲和力和选择性、代谢稳定性和细胞摄取。