Gordon Conference on Myelin

描述（由申请人提供）：在此申请中，我们要求支持将于2004年5月23日至28日在意大利巴尔加Ciocci举行的第七届戈登髓磷脂会议。自上次会议以来，髓鞘生物学领域取得了重大进展，包括表征髓鞘细胞发育关键步骤的转录因子，确定在多发性硬化症等疾病中控制髓鞘再生细胞行为的细胞机制，以及解开轴突-胶质连接处的分子复合物。新的脱髓鞘动物模型的发展有望为髓磷脂的正常功能及其在各种病理中的功能障碍提供进一步的关键见解。第七次会议的计划是为了强调我们对髓磷脂和髓鞘细胞生物学及其在疾病中的作用的理解的新进展。已注意尽量减少与上届会议或同一年相关会议的发言者重叠，并扩大会议的重点，而不仅仅是“髓磷脂”。髓磷脂和髓鞘细胞生物学的研究是；然而，随着研究膜运输，细胞信号传导和细胞迁移的不同方面的科学家的招募，正在经历一个扩张时期。该项目旨在吸引直接研究髓磷脂及其相关细胞以及脑肿瘤生物学和再生相关领域的科学家。这种增强的多样性将继续增加髓磷脂相关科学家的多样性，并提供一个充满活力和广谱的会议。为了特别鼓励年轻研究人员的参与，在资金许可的情况下，将提供注册和旅行津贴。所有与会者将被要求作出口头报告或出示海报。除正式会议外，广泛的海报会议将鼓励具有不同专业知识的科学家之间进行富有成效的互动，并与戈登会议组织的目标保持一致；这种协同作用将为髓磷脂生物学领域提供重要的推动力和指导。

DESCRIPTION (provided by applicant): In this application we are requesting support for the seventh Gordon conference on Myelin to be held in II Ciocci, Barga, Italy from May 23-28, 2004. The field of myelin biology has seen significant advances since the last meeting including the characterization of transcription factors regulating critical steps in the development of myelinating cells, the identification of cellular mechanisms that control the behavior of remyelinating cells in diseases such as Multiple Sclerosis and the unraveling of the molecular complexes at axonal-glial junctions. The development of new animal models of demyelination promises to provide further critical insights into the normal function of myelin and its dysfunction in a variety of pathologies. The program for this 7th meeting has been developed to highlight these new advances in our understanding of the biology of myelin and myelinating cells and their role in disease. Care has been taken to minimize overlap in speakers with the previous meeting, or with related meetings in the same year and to expand the focus of the meeting beyond simply "myelin". The study of myelin and the biology of myelinating cells is; however, undergoing a period of expansion with the recruitment of scientists studying diverse aspects of membrane trafficking, cell signaling and cell migration. The program has been designed to attract scientists working both directly on myelin and its associated cells as well as in related areas of brain tumor biology and regeneration. This enhanced diversity will continue to increase the variety of myelin-associated scientist and provide for a dynamic and broad-spectrum meeting. To specifically encourage the participation of young investigators, registration and travel stipends will be offered as funds permit. All attendees will be expected to contribute to an oral presentation or present a poster. In addition to formal sessions, extensive poster sessions will encourage productive interactions between scientists with different expertise and in keeping with the goals of the Gordon Conference organization; such synergy will provide critical impetus and guidance to the field of myelin biology.