Plasminogen Activation/Extracellular Proteolysis Conf.

纤溶酶原激活/细胞外蛋白水解会议。

• 批准号: 6708487
• 负责人: Daniel A Lawrence
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6708487
• 关键词: endopeptidases; meeting /conference /symposium; plasminogen; proteolysis; travel

DESCRIPTION (provided by applicant): This application is for partial support of the eighth Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis to be held at the Harbortown Sheraton Inn in Ventura California on February 8-13, 2004. This is an international conference that was formerly called Thrombolysis, and has been held every two years since 1990. Since its inception, the conference has evolved from its original format into a broader forum for an in-depth discussion of the most exciting, cutting-edge developments in the field of plasminogen activation and extracellular proteolysis. This evolution was formally recognized in the last conference, which voted to change the conference title to "Plasminogen Activation and Extracellular Proteolysis". Topics for the current meeting reflect this broader scope and have been selected based on the input of past attendees, with particular attention to the recommendations of past chairs. New advances in both basic and clinical science will be covered. Emphasis will be placed on emerging relationships between the plasminogen activator system and other proteolytic systems, including transmembrane serine proteases and metalloproteases, in development, tissue repair, vascular disease, tumor progression, thrombolysis, neuronal function, Alzheimer's disease and stroke. Emphasis will be placed on mechanistic insights into interplay of proteases, their receptors, and inhibitors in disease. Nine sessions are planned and will cover: 1. Thrombolysis in the Post Genomic World; 2. Plasminogen Activation and Disease; 3. Thrombosis and Fibrinolysis; 4. Proteases and Inhibitors in Neurobiology; 5. Plasminogen Independent Extracellular Proteolysis; 6. Rational Drug Design and Plasminogen Activators; 7. Late breaking topics and presentation of selected posters; 8. Protease Receptors and Signaling; 9. Transmembrane Serine Proteases. Thus, the goals of the conference are to provide a comprehensive state-of-the-art understanding of basic biologic processes and clinical advances related to extracellular protease systems in blood and tissues.

描述(由申请人提供)：本申请是对将于2004年2月8日至13日在加利福尼亚州文图拉的哈博敦喜来登酒店举行的第八届戈登纤溶酶原激活和胞外蛋白分解研究会议的部分支持。这是一个国际会议，以前被称为溶栓，自1990年以来每两年举行一次。自成立以来，会议已从最初的形式演变为一个更广泛的论坛，深入讨论纤溶酶原激活和细胞外蛋白分解领域最令人兴奋的前沿发展。这一进化在上一次会议上得到了正式认可，会议投票将会议名称改为“纤溶酶原激活和胞外蛋白分解”。本次会议的议题反映了这一更广泛的范围，是根据以往与会者的意见选择的，并特别注意了以往主席的建议。本课程将涵盖基础和临床科学方面的新进展。重点将放在纤溶酶原激活系统和其他蛋白分解系统之间的新出现的关系，包括在发育、组织修复、血管疾病、肿瘤进展、血栓溶解、神经功能、阿尔茨海默病和中风中的跨膜丝氨酸蛋白酶和金属蛋白酶。重点将放在对蛋白酶、其受体和抑制物在疾病中相互作用的机械性见解上。计划举办九次会议，内容包括： 1.后基因组世界的溶栓； 2.纤溶酶原激活与疾病； 3.血栓形成和纤溶； 4.神经生物学中的蛋白水解酶和抑制剂； 5.非纤溶酶原胞外蛋白水解酶； 6.合理的药物设计和纤溶酶原激活剂； 7.最新的主题和精选海报的呈现； 8.蛋白水解酶受体与信号传导； 9.跨膜丝氨酸蛋白酶。 因此，会议的目标是全面了解血液和组织中与细胞外蛋白水解酶系统相关的基本生物过程和临床进展。