Administrative Supplement for ASIC design project

总结 根据一项积极的第二阶段提案，神经动力学技术公司。将开发可定制的， 具有集成闭环功能的高密度探头，可长期植入， 用于头部固定或能够自由移动的动物。我们阶段的第一个目标 II建议是将光传输和电刺激功能集成到我们的探头上， 实现闭环实验。光输送和电刺激的位置将 可以定制，以便客户可以指定他们想要的位置。第二个目标是 开发涉及构建专用集成电路的封装方法 （ASIC）和相关硬件，可以控制所有集成功能。ASIC将在 与专门的集成电路设计公司和半导体公司合作开发 铸造厂组合包装的装置将足够小，以使慢性实验， 头部固定或自由移动的动物。在本行政补充文件中，我们要求 额外的预算来支付创建这个ASIC的成本。与精心挑选的 和美国的ASIC设计公司，NDT将设计创新的闭环接口， 因果关系的研究，解决不同的大脑区域和神经元类型的功能作用， 头部固定和自由移动的动物的大脑。这些类型的闭环装置可以 进一步演变成神经植入物来治疗神经系统疾病，如难治性癫痫， 帕金森氏症和其他震颤性疾病。

SUMMARY Under an active Phase II proposal, Neural Dynamics Technologies Inc. will develop customizable, high-density probes with integrated closed-loop capabilities that can be chronically implanted for use in animals that are either head-fixed or able to move around freely. The first aim of our Phase II proposal is to integrate light delivery and electrical stimulation capabilities onto our probes to enable closed-loop experimentation. The locations for light delivery and electrical stimulation will be customizable so that customers can specify their desired location. The second aim will be to develop a packaging approach that involves building an application specific integrated circuit (ASIC) and associated hardware that can control all integrated functionalities. This ASIC will be developed in partnership with a dedicated integrated circuit design firm and semiconductor foundry. The combined packaged device will be small enough to enable chronic experiments in either head-fixed or freely moving animals. In this administrative supplement we are requesting additional budget to cover the cost of creating this ASIC. In partnership with a carefully chosen and US based ASIC design firm, NDT will design innovative closed-loop interfaces that will enable causal studies addressing the functional role of different brain regions and neuron types in the brains of both head-fixed and freely moving animals. These types of closed-loop devices may be further evolved into neural implants to treat neurological diseases such as refractory epilepsy, Parkinson’s and other tremor disorders.