Administrative Supplement for ASIC design project

ASIC 设计项目的行政补充

• 批准号: 10844225
• 负责人: Ingrid van Welie
• 金额: $ 55.27万
• 依托单位: NEURAL DYNAMICS TECHNOLOGIES INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-18 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10844225
• 关键词: Address; Administrative Supplement; Animals; Brain; Brain Diseases; Brain region; Budgets; Chronic; Chronic Disease; Dedications; Development; Devices; Disease; Electric Stimulation; Head; Implant; Individual; Intractable Epilepsy; Light; Location; Measures; Morphology; Neurons; Parkinson Disease; Phase; Role; Semiconductors; Specific qualifier value; Technology; Tremor; cost; density; design; experimental study; in vivo; innovation; integrated circuit; nervous system disorder; neural; neural circuit; neural implant; therapeutically effective

SUMMARY Under an active Phase II proposal, Neural Dynamics Technologies Inc. will develop customizable, high-density probes with integrated closed-loop capabilities that can be chronically implanted for use in animals that are either head-fixed or able to move around freely. The first aim of our Phase II proposal is to integrate light delivery and electrical stimulation capabilities onto our probes to enable closed-loop experimentation. The locations for light delivery and electrical stimulation will be customizable so that customers can specify their desired location. The second aim will be to develop a packaging approach that involves building an application specific integrated circuit (ASIC) and associated hardware that can control all integrated functionalities. This ASIC will be developed in partnership with a dedicated integrated circuit design firm and semiconductor foundry. The combined packaged device will be small enough to enable chronic experiments in either head-fixed or freely moving animals. In this administrative supplement we are requesting additional budget to cover the cost of creating this ASIC. In partnership with a carefully chosen and US based ASIC design firm, NDT will design innovative closed-loop interfaces that will enable causal studies addressing the functional role of different brain regions and neuron types in the brains of both head-fixed and freely moving animals. These types of closed-loop devices may be further evolved into neural implants to treat neurological diseases such as refractory epilepsy, Parkinson’s and other tremor disorders.

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