Sensorimotor Control of the Human Orofacial System

人类口面部系统的感觉运动控制

• 批准号: 6838747
• 负责人: STEVEN M BARLOW
• 金额: $ 40.65万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-15 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6838747
• 关键词: assistive device /technology; behavioral /social science research tag; biomechanics; developmental neurobiology; electromyography; electrophysiology; face; human subject; human therapy evaluation; infant human (0-1 year); intubation; longitudinal human study; mouth; neural plasticity; neuromuscular disorder; neuromuscular system; oral behavior; premature infant human; reflex; rehabilitation; respiratory disorder; respiratory system; sensorimotor system; sensory feedback; stimulus /response

DESCRIPTION (provided by applicant): The proposed studies are intended to expand our understanding of sensorimotor integration in the neonate and infant orofacial system during patterned oromotor output [non-nutritive suck -- NNS] using a servo-controlled ACTIFIER. Three specific aims have been formulated to investigate the sensorimotor apparatus of the neonate orofacial system using a novel electrophysiologic technique to index the excitability of trigeminofacial pathways during NNS in term and pre-term infants. The ability to modulate the organization of patterned oromotor output will be explored using mechanosensory entrainment, and finally, some principles of neuroplasticity will be tested in habilitating neonates in the intensive care nursery who manifest dysfunctional oromotor control. Simultaneous recordings of chest wall kinematics are included as a control measure to assess the nature and specificity of perioral stimulation on respiratory patterning. The proposed habilitation strategy, utilizing natural mechanical stimulation, has ecological validity in assisting the infant to produce an appropriate motor output. Moreover, this approach is consistent with the contention that appropriate oral experiences may be critical in the final weeks of gestation, and that their interruption may impair fragile syntheses of central neural representations of functions.

描述（由申请人提供）：拟议的研究旨在 扩大我们对新生儿和婴儿感觉运动整合的理解 模式化口腔运动输出期间的口面部系统 [非营养性吸吮 - NNS] 使用伺服控制的 ACTIFIER。制定了三项具体目标 使用以下方法研究新生儿口面部系统的感觉运动装置 新颖的电生理技术来指数三叉面神经的兴奋性 足月儿和早产儿 NNS 期间的途径。调制能力 将使用机械感觉探索模式化口部运动输出的组织 最后，神经可塑性的一些原理将在 使重症监护室中表现出功能障碍的新生儿康复 口腔运动控制。包括胸壁运动学的同步记录 作为评估口周的性质和特异性的控制措施 对呼吸模式的刺激。拟议的康复策略， 利用自然机械刺激，在协助方面具有生态有效性 婴儿产生适当的运动输出。而且，这种方法是 与以下观点一致：适当的口头经验可能是 在妊娠的最后几周至关重要，中断可能会 损害中枢神经功能表征的脆弱综合。