Sensorimotor Control of the Human Orofacial System

人类口面部系统的感觉运动控制

基本信息

  • 批准号:
    7528830
  • 负责人:
  • 金额:
    $ 53.49万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-01-15 至 2013-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): A new synthetic patterned orocutaneous stimulation technique (NTrainer) has been shown previously to entrain the suck central pattern generator (sCPG) in human infants. The effectiveness of the NTrainer will be tested in a randomized trial among four groups of preterm infants. Three of the clinical populations selected are especially at risk for significant oromotor dysfunction and feeding difficulties, including babies with (1) moderate-severe history of respiratory distress syndrome (RDS), (2) chronic lung disease and/or bronchopulmonary dysplasia (CLD/BPD), and (3) infants with Down syndrome (DS). Preterm infants distributed among these groups with birth gestational ages between 26 and 32 weeks will be randomly assigned to experimental (Treatment w/NTrainer) and control (No Treatment sham stimulation) subgroups. The fourth group will consist of HEALTHY preterm infants. It is hypothesized that premature infants with a significant history of RDS, CLD/BPD, and Down syndrome will demonstrate significant reorganization and activation of the sCPG following NTrainer treatment. Primary outcome variables include daily measures of non-nutritive suck dynamics (NeoSuck), spatiotemporal index of the non-nutritive suck (STI NNS), ororhythmic motor behavior, NNS cycle period analysis, early feeding skills assessment, transition time from tube-to-oral feed, feeding efficiency, and length of hospital stay. A second major objective will include a comprehensive assessment of neurodevelopmental outcome at 3 years of age. The Bayley III Developmental Scales and a battery of standardized articulation, vocabulary, grammar, and speech-language probes will provide vital information on production and reception. These measures will assess the potential link between oromotor status in prematurity, effects of NTrainer stimulation, and neurodevelopmental outcome. Prematurity is the leading cause of developmental disabilities in children, including cerebral palsy, mental retardation, blindness, chronic lung problems, attention deficit, and speech/language disorders. Feeding competency is another challenging hurdle facing many premature babies, especially for those who have an extensive oxygen history associated with respiratory disease, neurologic insult, or certain genetic defects which impair oromotor development. The lengthy intubation procedures cost the baby precious sensory and motor experiences during a critical period of brain development for oromotor pattern generation. Accelerated development of oromotor skills using a novel method for delivering patterned orocutaneous stimulation to the oral sensorium will directly benefit this growing population of fragile infants, leading to enhanced suck skills, decreased transition time from gavage tube-to-oral feed, decreased length of hospitalization, and promote a more positive neurodevelopmental outcome. PUBLIC HEALTH RELEVANCE: Prematurity is rising at an alarming rate in the United States, associated with 1 in 8 live births. Prematurity occurs during a critical period of brain development and is the leading cause of developmental disabilities in children, including cerebral palsy, mental retardation, blindness, chronic lung problems, attention deficit, and speech/language disorders. Feeding competency is another challenging hurdle facing many premature babies who have respiratory disease, brain injury, or certain genetic defects which impair oral development. A new medical device known as the NTrainer will be tested in a randomized trial among 240 tube-fed premature infants in order to determine if a novel synthetic oral stimulation therapy can effectively accelerate development of suck and feeding skills, enhance brain development, decrease the length of hospitalization, and improve speech-language and motor skills measured at 3 years of age.
描述(由申请人提供):一种新的合成模式化口腔皮肤刺激技术(NTrainer)先前已被证明可在人类婴儿中携带吸吮中枢模式发生器(sCPG)。NTrainer的有效性将在四组早产儿中进行随机试验。所选的三个临床人群尤其具有显著的呼吸功能障碍和喂养困难的风险,包括(1)有中度至重度呼吸窘迫综合征(RDS)病史的婴儿,(2)慢性肺病和/或支气管肺发育不良(CLD/BPD)的婴儿,和(3)患有唐氏综合征(DS)的婴儿。分布在这些组中的出生胎龄在26至32周之间的早产儿将被随机分配到实验组(使用NTrainer进行治疗)和对照组(不进行治疗 假刺激)亚组。第四组为健康的早产儿。假设有RDS、CLD/BPD和唐氏综合征显著病史的早产儿在NTrainer治疗后将表现出sCPG的显著重组和激活。主要结局变量包括非营养性吮吸动力学的每日测量(NeoSuck)、非营养性吮吸的时空指数(STI NNS)、节律运动行为、NNS周期分析、早期喂养技能评估、从管饲到口饲的过渡时间、喂养效率和住院时间。第二个主要目标将包括在3岁时对神经发育结果进行全面评估。Bayley III发育量表和一系列标准化的发音、词汇、语法和语音语言探测器将提供有关生产和接收的重要信息。这些措施将评估早产儿的睾丸功能状态、NTrainer刺激的影响和神经发育结局之间的潜在联系。早产是儿童发育障碍的主要原因,包括脑瘫、智力迟钝、失明、慢性肺病、注意力缺陷和言语/语言障碍。喂养能力是许多早产儿面临的另一个具有挑战性的障碍,特别是对于那些患有呼吸系统疾病、神经损伤或某些损害骨骼发育的遗传缺陷的早产儿。漫长的插管过程使婴儿在大脑发育的关键时期失去了宝贵的感觉和运动经验,以产生听觉模式。使用一种向口腔感觉区提供模式化口皮刺激的新方法加速口腔技能的发展将直接使这一不断增长的脆弱婴儿群体受益,从而增强吸吮技能,减少从管饲到经口喂养的过渡时间,缩短住院时间,并促进更积极的神经发育结果。公共卫生相关性:在美国,早产率正以惊人的速度上升,每8个活产婴儿中就有1个早产。早产发生在大脑发育的关键时期,是儿童发育障碍的主要原因,包括脑瘫、智力低下、失明、慢性肺部问题、注意力缺陷和言语/语言障碍。喂养能力是许多患有呼吸系统疾病、脑损伤或某些影响口腔发育的遗传缺陷的早产儿面临的另一个挑战性障碍。一种名为NTrainer的新医疗设备将在240名管饲早产儿中进行随机试验,以确定一种新型的合成口腔刺激疗法是否可以有效地加速吸吮和喂养技能的发展,增强大脑发育,减少住院时间,并改善3岁时测量的语言和运动技能。

项目成果

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STEVEN M BARLOW其他文献

STEVEN M BARLOW的其他文献

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{{ truncateString('STEVEN M BARLOW', 18)}}的其他基金

Somatosensory Modulation of Salivary Gene Expression and Oral Feeding in Preterm Infants
早产儿唾液基因表达和口服喂养的体感调节
  • 批准号:
    9900587
  • 财政年份:
    2016
  • 资助金额:
    $ 53.49万
  • 项目类别:
Somatosensory Modulation of Salivary Gene Expression and Oral Feeding in Preterm Infants
早产儿唾液基因表达和口服喂养的体感调节
  • 批准号:
    9007202
  • 财政年份:
    2016
  • 资助金额:
    $ 53.49万
  • 项目类别:
Digital and Electrical Engineering
数字与电气工程
  • 批准号:
    8116464
  • 财政年份:
    2010
  • 资助金额:
    $ 53.49万
  • 项目类别:
Sensorimotor Control of the Human Orofacial System
人类口面部系统的感觉运动控制
  • 批准号:
    7850332
  • 财政年份:
    2009
  • 资助金额:
    $ 53.49万
  • 项目类别:
Digital and Electrical Engineering
数字与电气工程
  • 批准号:
    7671416
  • 财政年份:
    2008
  • 资助金额:
    $ 53.49万
  • 项目类别:
Digital and Electrical Engineernig Core
数字和电气工程核心
  • 批准号:
    7278422
  • 财政年份:
    2005
  • 资助金额:
    $ 53.49万
  • 项目类别:
Sensorimotor Control of the Human Orofacial System
人类口面部系统的感觉运动控制
  • 批准号:
    8828835
  • 财政年份:
    2002
  • 资助金额:
    $ 53.49万
  • 项目类别:
Sensorimotor Control of the Human Orofacial System
人类口面部系统的感觉运动控制
  • 批准号:
    6688318
  • 财政年份:
    2002
  • 资助金额:
    $ 53.49万
  • 项目类别:
Sensorimotor Control of the Human Orofacial System
人类口面部系统的感觉运动控制
  • 批准号:
    6838747
  • 财政年份:
    2002
  • 资助金额:
    $ 53.49万
  • 项目类别:
Sensorimotor Control of the Human Orofacial System
人类口面部系统的感觉运动控制
  • 批准号:
    6434722
  • 财政年份:
    2002
  • 资助金额:
    $ 53.49万
  • 项目类别:

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    10457019
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  • 批准号:
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  • 批准号:
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