Protective Mechanisms of CO in Intestinal Inflammation

CO对肠道炎症的保护机制

基本信息

  • 批准号:
    6923425
  • 负责人:
  • 金额:
    $ 29.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-07-01 至 2010-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Postoperative ileus, the impaired intestinal contractility following abdominal surgery, continues to be a major clinical problem, extending hospital stay and contributing to medical complications. We and others have observed that operative procedures initiate pro-inflammatory molecular events within the muscle layer of the G.I. tract which underlie the development of intestinal dysmotility. Furthermore, differences in the onset and resolution of inflammation have been identified in the small bowel and colon. The role of anti-inflammatory mechanisms in the resolution of inflammation and restoration of function are still ill-defined. We hypothesize that the early induction of anti-inflammatory pathways, or providing the endproducts of these pathways, could be exploited therapeutically to limit inflammation and reduce or prevent the functional and molecular manifestations of postoperative ileus. The inducible isoform of the enzyme heme oxygenase, HO-1, is a ubiquitous stress response protein that is highly induced by a variety of stress-related conditions. Studies report that early induction of HO-1, or exposure by inhalation to very low concentrations of CO, a normal byproduct of HO-1 activity, is highly protective against inflammatory injury. The proposed studies will establish signaling mechanisms by which CO-induced anti-inflammatory pathways protect the gut from the functional and molecular manifestations of inflammation. CO exposure constitutes a novel and non-invasive technique to determine how regional differences in pro- and anti-inflammatory signaling events are regulated, findings that have important implications for clinical management strategies, not just for intestinal inflammation, but also other organ systems. Specific aims: AIM 1: Determine whether exposure to CO prior to colonic surgery will attenuate colonic dysmotility. AIM 2: Determine effects of CO exposure on pro- and anti-inflammatory mediator expression (transcription, translation, enzyme activity) in the colon. AIM 3: Identify the mechanistic pathways by which CO alters pro- and anti-inflammatory signaling, and identify regional differences.
描述(由申请人提供):术后肠梗阻,腹部手术后肠道收缩功能受损,一直是一个主要的临床问题,延长住院时间并导致医学并发症。我们和其他人已经观察到,手术过程在胃肠道肌肉层内启动促炎分子事件,这是肠道运动障碍发展的基础。此外,小肠和结肠炎症的发生和消退也存在差异。抗炎机制在炎症消退和功能恢复中的作用仍不明确。我们假设,早期诱导抗炎途径,或提供这些途径的最终产物,可以用于治疗,以限制炎症,减少或预防术后肠梗阻的功能和分子表现。血红素加氧酶的诱导异构体HO-1是一种普遍存在的应激反应蛋白,可被各种应激相关条件高度诱导。研究报告称,早期诱导HO-1,或通过吸入极低浓度的CO (HO-1活性的正常副产物),对炎症损伤具有高度保护作用。这些研究将建立co诱导的抗炎途径保护肠道免受炎症的功能和分子表现的信号机制。一氧化碳暴露是一种新的非侵入性技术,可以确定促炎和抗炎信号事件的区域差异是如何调节的,这一发现对临床管理策略具有重要意义,不仅适用于肠道炎症,也适用于其他器官系统。目的1:确定结肠手术前暴露于CO是否会减轻结肠运动障碍。目的2:确定CO暴露对结肠中促炎和抗炎介质表达(转录、翻译、酶活性)的影响。目的3:确定CO改变促炎和抗炎信号的机制途径,并确定区域差异。

项目成果

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ANTHONY J BAUER其他文献

ANTHONY J BAUER的其他文献

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{{ truncateString('ANTHONY J BAUER', 18)}}的其他基金

Protective Mechanisms of CO in Intestinal Inflammation
CO对肠道炎症的保护机制
  • 批准号:
    7263899
  • 财政年份:
    2005
  • 资助金额:
    $ 29.59万
  • 项目类别:
Protective Mechanisms of CO in Intestinal Inflammation
CO对肠道炎症的保护机制
  • 批准号:
    7089013
  • 财政年份:
    2005
  • 资助金额:
    $ 29.59万
  • 项目类别:
Protective Mechanisms of CO in Intestinal Inflammation
CO对肠道炎症的保护机制
  • 批准号:
    7646299
  • 财政年份:
    2005
  • 资助金额:
    $ 29.59万
  • 项目类别:
Protective Mechanisms of CO in Intestinal Inflammation
CO对肠道炎症的保护机制
  • 批准号:
    7467952
  • 财政年份:
    2005
  • 资助金额:
    $ 29.59万
  • 项目类别:
INTESTINAL INFLAMMATORY SYNERGY BETWEEN HEMORRHAGIC SHOCK AND TRAUMA
失血性休克和创伤之间的肠道炎症协同作用
  • 批准号:
    6829218
  • 财政年份:
    2004
  • 资助金额:
    $ 29.59万
  • 项目类别:
POSTOPERATIVE ILEUS INDUCED BY SURGICAL TRAUMA
手术创伤引起的术后肠梗阻
  • 批准号:
    6525470
  • 财政年份:
    1998
  • 资助金额:
    $ 29.59万
  • 项目类别:
Triggering Mechanisms of Post-Operative Ileus
术后肠梗阻的触发机制
  • 批准号:
    7077751
  • 财政年份:
    1998
  • 资助金额:
    $ 29.59万
  • 项目类别:
POSTOPERATIVE ILEUS INDUCED BY SURGICAL TRAUMA
手术创伤引起的术后肠梗阻
  • 批准号:
    6019508
  • 财政年份:
    1998
  • 资助金额:
    $ 29.59万
  • 项目类别:
Triggering Mechanisms of Post-Operative Ileus
术后肠梗阻的触发机制
  • 批准号:
    6920534
  • 财政年份:
    1998
  • 资助金额:
    $ 29.59万
  • 项目类别:
POSTOPERATIVE ILEUS INDUCED BY SURGICAL TRAUMA
手术创伤引起的术后肠梗阻
  • 批准号:
    6180890
  • 财政年份:
    1998
  • 资助金额:
    $ 29.59万
  • 项目类别:

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