X-ray imaging using edge-on-microchannel plate detectors

使用边缘微通道板探测器进行 X 射线成像

• 批准号: 6884583
• 负责人: SABEE MOLLOI
• 金额: $ 23.94万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6884583
• 关键词: X ray; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; calcification; charge coupled device camera; computed axial tomography; computer program /software; electromagnetic radiation; image enhancement; imaging /visualization /scanning; mammography; monitoring device; radiation dosage; radiography; radiology

DESCRIPTION (provided by applicant): A diagnostic X-ray imaging system is required to simultaneously have high contrast, high resolution and be fast with low dose to the patient. High contrast and low dose requirements are of a particular interest in mammography, where low contrast tumors and microcalcifications are to be detected at high scatter levels. The limitations of the currently scanning slot systems include the inherently high noise level of the CCD, suboptimal conversion efficiency, limited charge capacity of the CCD and its relatively high scatter fraction (up to 20%) due to its wide scanning slot. The purpose of this project is to develop a scanning multi-slit X-ray imaging system based on an "edge-on" illuminated microchannel plate (MCP) detector for potential application in mammography. The advantages of an "edge-on" MCP detector over other types of X-ray detectors are the possibility to combine high stopping power, superior spatial resolution, direct energy-tocharge conversion, high physical charge amplification and very low noise. More specifically, the aims are: (1) Design and development of a scanning slit X-ray imaging system based on "edge-on" MCP detector and delay line electronics for digital mammography. (2) Investigation of the hypothesis that an X-ray imaging system based on "edge-on" MCP detector can offer substantially improved detection quantum efficiency, resolution, noise and scatter fraction as compared to other currently available mammography systems. (3) Design and development of chip level application specific integrated circuit (ASIC) electronics with very highcount rate capability. (4) Development and evaluation of a clinically applicable single slit prototype X-ray imaging system based on "edge-on" MCP detector with ASIC electronics. (5) Design of a clinically applicable multi-slit x-ray imaging system for digital mammography. The proposed multi-slit X-ray imaging system based on an "edge-on" MCP detector will be photon counting, quantum limited and low scatter fraction. It can potentially provide a high-resolution detector with significant reduction in patient dose for digital mammography.

描述（由申请人提供）： 诊断X射线成像系统需要同时具有高对比度、高分辨率和快速且对患者的剂量低。高对比度和低剂量要求在乳房X线摄影中特别令人感兴趣，其中低对比度肿瘤和微钙化将在高散射水平下被检测。当前扫描槽系统的局限性包括CCD固有的高噪声水平、次优转换效率、CCD有限的电荷容量以及由于其宽扫描槽而导致的其相对高的散射分数（高达20%）。本计画的目的是发展一种基于边缘照射式微通道板（MCP）探测器的扫描多狭缝X射线成像系统，以应用于乳房摄影。与其他类型的X射线探测器相比，“边缘上”MCP探测器的优点是可以联合收割机高阻止能力、上级的空间分辨率、直接能量-电荷转换、高物理电荷放大和非常低的噪声。具体而言，本论文的目标是：（1）设计和开发一种用于数字乳腺X射线摄影的基于边缘上MCP探测器和延迟线电子学的扫描狭缝X射线成像系统。(2)与其他当前可用的乳腺X射线摄影系统相比，基于“边缘上”MCP探测器的X射线成像系统可以提供显著改善的探测量子效率、分辨率、噪声和散射分数的假设的研究。(3)设计和开发具有极高计数率能力的芯片级专用集成电路（ASIC）电子产品。(4)基于“边缘上”MCP探测器和ASIC电子器件的临床适用单缝原型X射线成像系统的开发和评价。(5)临床应用的数字乳腺摄影多缝x射线成像系统的设计。提出的多缝X射线成像系统的基础上的“边缘上”MCP探测器将光子计数，量子限制和低散射分数。它可以提供一种高分辨率探测器，显著降低数字乳腺X射线摄影的患者剂量。