Quantification of coronary calcium mass by dual energy fluoroscopy

双能荧光透视法定量冠状动脉钙质量

基本信息

批准号：
7636737
负责人：
SABEE MOLLOI
金额：
$ 37.41万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-08-01 至 2012-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Effective preventive strategies require early detection of sub-clinical atherosclerotic heart disease. Radiographic detection and quantification of coronary artery calcium has undergone extensive research in this regard. There is a strong association between coronary calcium and both pathologic findings and coronary events. Most recent research has utilized computed tomography for evaluating coronary calcium. Fluoroscopic evaluation is limited by low sensitivity, due to interfering background tissue structures and inability to objectively quantify calcium content. Dual energy imaging does not suffer from these two limitations and offers a lower dose and lower cost solution to early detection of atherosclerosis. The proposed research will develop a motion insensitive dual energy subtraction technique that will provide densitometry measurements of coronary calcium. More specifically, the aims are: (1) Investigation of the hypothesis that the absolute calcium mass in coronary arteries can be accurately measured using a densitometry technique with phantom and animal studies. The densitometry analysis will be performed on tissue suppressed dual energy images and will yield absolute (as opposed to relative) calcium mass. (2) To test the hypothesis that calcium mass measured in human volunteers with dual-energy fluoroscopy and calcium score measured with electron beam computed tomography have a Spearman correlation coefficient higher than 0.95. (3) To establish the presence or absence of a difference between the two technologies in discriminating persons with prevalent coronary heart disease from those without prevalent coronary heart disease. This research will provide a method to non-invasively quantify coronary artery calcium using dual energy imaging. Most likely, cardiac imaging with image intensifier television based systems will be replaced with flat-panel detectors in the coming years. As the rapid development in the last few years has shown, the new digital systems will allow development of more sophisticated analysis techniques. Densitometry based quantification of coronary artery calcium mass is one promising analytical technique that new digital systems may provide. To date, the sensitivity of temporal subtraction to cardiac motion has hampered the development of digital image processing techniques for cardiac imaging. Dual-energy imaging, because of its motion insensitivity, can serve as a foundation for quantitative cardiac analysis to proceed.

描述（由申请人提供）：有效的预防策略需要尽早发现亚临床动脉粥样硬化心脏病。在这方面，冠状动脉钙的放射学检测和定量已经进行了广泛的研究。冠状动脉钙与病理发现与冠状动脉事件之间存在很强的关联。最近的研究利用计算机断层扫描来评估冠状动脉钙。荧光镜评估受到低灵敏度的限制，这是由于背景组织结构干扰并且无法客观地量化钙含量。双能量成像不会受到这两个局限性的影响，并且为早期检测动脉粥样硬化提供了较低的剂量和较低的成本解决方案。拟议的研究将开发运动不敏感的双能量减法技术，该技术将提供冠状动脉钙的光密度测量值。更具体地说，目的是：（1）研究假设，即可以使用幻影和动物研究的光密度测定法准确地测量冠状动脉中的绝对钙质量。光密度分析将在抑制双能图像的组织上进行，并产生绝对（与相对）钙质量的绝对（相对）。（2）测试以下假设：在人类志愿者中测得的钙质量，具有双能量荧光镜检查和用电子束计算机断层扫描测量的钙评分的钙质量，其长矛曼相关系数高于0.95。（3）确定两种技术之间存在或不存在差异，以区分患有冠心病的患者与没有普遍的冠状动脉疾病的人。这项研究将提供一种使用双能量成像的非侵入性量化冠状动脉钙的方法。在未来几年中，最有可能用图像增强电视系统的心脏成像将被平板探测器取代。正如过去几年所表明的快速发展一样，新的数字系统将允许开发更复杂的分析技术。基于密度计的冠状动脉钙质量定量是新数字系统可以提供的一种有希望的分析技术。迄今为止，时间减法对心脏运动的敏感性阻碍了心脏成像的数字图像处理技术的发展。双能成像由于其运动不敏感，可以作为定量心脏分析进行的基础。