Modelling failure mechanisms in total ankle replacement

几十年来，全关节置换术已成为全球数百万患者成功治疗终末期骨关节炎的手术干预手段。尽管如此，全踝关节置换术（TAR）的临床结果相对较差-高达20%的植入物在10年内失败。因此，在本发明中，TAR --一种保留关节功能的干预--比踝关节融合术--一种限制踝关节活动范围的干预--使用得更少。该项目旨在开发实验模拟，通过对回收失败的形态学和几何学分析，模拟全踝关节置换术失败的机制--从以前的研究中扩大外科医生和器械设计的范围，以确保器械/外科医生--减轻了特定的故障机制。确定全踝关节置换术中可能出现的功能状况范围将用于对该设备的生物力学功能进行建模。这将输入到复制全踝关节置换生物力学的实验模型中，以便实验研究能够产生临床相关的失效机制。

Total joint replacement has been a successful surgical intervention for end-stage osteoarthritis for millions of patients globally for several decades. Despite this, clinical outcomes for total ankle replacement (TAR) have been comparatively poor - with up to 20% of implants failing before 10 years. As a result, TAR - an intervention which preserves joint function - has been used less commonly than ankle fusion - an intervention which limits ankle range of motionThis project aims to develop experimental simulation to model the mechanisms for failure of total ankle replacement through morphological and geometrical analysis of failed retrievals - broadening the range of surgeons and device designs from previous studies to ensure device/surgeon-specific failure mechanisms are mitigated. Determination of the envelope of functional conditions likely in a total ankle replacement will be used to model biomechanical function of the device. This will feed into experimental models that replicate the biomechanics of total ankle replacement such that experimental studies are able to generate clinically relevant failure mechanisms.