FASEB Summer Conference on Phospholipases

描述（由申请人提供）：本申请为FASEB于2004年7月17日至7月22日在乔治亚州松山卡拉威花园举行的磷脂酶夏季研究会议寻求部分资金。这将是第七次亚太经社会会议。申请的资金将专门用于支持参加会议的初级研究人员的注册和差旅费，他们将以受邀演讲、简短演讲或海报的形式展示他们的工作。这次成功召开的会议的主要目的是提供一种形式来回顾和讨论磷脂酶的结构、功能和调控方面的最新研究。磷脂酶是催化膜磷脂中酯和磷酸二酯键水解的酶。这种广泛表达的酶的成员通过产生生物活性脂质和脂质衍生产品在细胞调节的许多方面发挥核心作用。磷脂酶A产生脂肪酸和溶血磷脂。这些酶启动产生受体活性脂质，包括溶血磷脂酸和花生四烯酸的类二十烷代谢物，并在癌症和炎症性疾病（包括哮喘）中发挥了良好的作用。磷脂酶C响应激动剂激活细胞表面受体产生磷酸肌醇和甘油三酯第二信使，磷脂酶D从磷脂酰胆碱产生磷脂酸，磷脂酸调节信号通路，偶联控制细胞生长、存活、运动和囊泡运输。会议还包括关于合成和降解鞘脂的酶的讨论，鞘脂在细胞应激反应和细胞凋亡中起作用，以及质谱分析脂质结构的会议。这次会议汇集了对这些酶有共同兴趣的科学家，他们来自不同的学科，包括生物物理学、结构生物学、细胞生物学和分子生物学。会议有一个强有力的记录，包括来自开始和成熟的研究人员的演讲，并为促进该领域的合作和新进展提供了一个有效的论坛。该学科领域得到了NIH的大力支持，由NIH各主要研究所提供的资金支持了400多个活跃项目。在过去的10年里，这个领域每年产生大约2000篇同行评议的研究论文。本提案所要求的资金将对支持这次会议作出宝贵的贡献。

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Research Conference on Phospholipases to be held from July 17- July 22 2004 in Callaway Gardens, Pine Mountain, Georgia. This will be the seventh ASB conference on this subject. The funds requested will be used exclusively to support the registration and travel expenses of junior investigators who will be attending the conference and presenting their work as invited presentations, short talks or posters. The broad goal of this successful and established conference is to provide a form for review and discussion of recent research on the structure, function and regulation of phospholipases which are enzymes that catalyze the hydrolysis of ester and phosphodiester bonds in membrane phospholipids. Members of this widely expressed class of enzymes play central roles in many aspects of cell regulation by producing bioactive lipids and lipid-derived products. Phospholipases A generate fatty acids and lysophospholipids. These enzymes initiate production of receptor-active lipids including lysophosphatidic acid and the eicosanoid metabolites of arachidonic acid and have well established roles in cancer and inflammatory diseases including asthma. Phospholipases C produce inositol phosphate and diglyceride second messengers in response to agonist activation of cell surface receptors and Phospholipases D generate phosphatidic acid from phosphatidylcholine which regulates signaling pathways coupled to control of cell growth, survival, motility and vesicular transport. The conference also includes talks on enzymes that synthesise and degrade sphingolipids that have roles in cellular stress responses and apoptosis as well as a session on analysis of lipid structures by mass spectrometry. This conference brings together scientists with a shared interest in these enzymes that are working in diverse disciplines including biophysics, structural, cell and molecular biology. The conference has a strong record of including presentations from beginning and established investigators and provides an effective forum for promoting collaborations and new advances in the field. The subject area is one that receives considerable support from the NIH with over 400 active projects sustained by funds provided by each of the major NIH institutes. For the past 10 years this field has generated about 2000 peer reviewed research publications each year. The funds requested in this proposal will make an invaluable contribution to the support of this conference.