Core B - Analytical Core

核心 B - 分析核心

• 批准号: 10225371
• 负责人: ANDREW J MORRIS
• 金额: $ 19.13万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10225371
• 关键词: Adipose tissue; Analytical Chemistry; Animals; Area; Award; Biological Assay; Biological Markers; Blood; Cardiovascular Diseases; Centers of Research Excellence; Clinical; Collaborations; Complex Mixtures; Core Facility; Coupled; Data; Development; Diet; Diet and Nutrition; Dietary Carbohydrates; Dietary Fats; Disease; Ecology; Ensure; Fees; Funding; Glucose; Goals; Grant; High Pressure Liquid Chromatography; Human; Incidence; Individual; Institution; Journals; Kentucky; Laboratories; Link; Lipids; Malignant Neoplasms; Mass Fragmentography; Mass Spectrum Analysis; Measures; Medicine; Methods; National Institute of Environmental Health Sciences; Neurodegenerative Disorders; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Obesity associated disease; Peer Review; Phase; Phospholipids; Pre-Clinical Model; Publications; Reporting; Research; Research Personnel; Research Support; Resolution; Resources; Risk Factors; Rural; Services; Structure; Testing; Time; Tissues; Tracer; Training and Education; Triglycerides; United States National Institutes of Health; Urine; analytical method; base; biomarker development; cardiovascular risk factor; cohort; college; computational platform; disorder risk; energy balance; fatty acid metabolism; human disease; human subject; instrumentation; interest; lipid metabolism; lipidomics; metabolic abnormality assessment; metabolic phenotype; obesity development; operation; programs; small molecule; stable isotope; western diet

The Phase III Analytical Core will support research into mechanisms linking obesity, lipid metabolism and human disease risk through continued use of facility core instrumentation and resources to develop and support a suite of analytical services tailored for studies of the relationship between diet, obesity and disease mechanisms using preclinical models and clinical approaches. In addition, expansion of services in lipidomics and stable isotope tracer studies will augment capabilities for small animal metabolic phenotyping. This core has developed extensive instrumentation that enables quantitation of a broad range of small molecules, untargeted profiling of lipids in complex mixtures, targeted quantification of biomarkers linking obesity to disease, and methods for studies of glucose and fatty acid metabolism. Each of these analytical capabilities are of direct relevance to studies focused on diet, nutrition, and obesity in disease development. This core has contributed data for more than 110 peer reviewed publications since 2008 in high impact journals, provided services for more than 60 investigators, and contributed to new grant awards in environmental sciences. The core is well equipped, and with expanded services is anticipated to develop self-sustaining capacity in Phase III of the COCVD.

第三阶段分析核心将支持对肥胖、脂肪代谢和 人类疾病风险，通过继续使用设施、核心仪器设备和资源来开发和 支持为研究饮食、肥胖和疾病之间的关系量身定做的一套分析服务 使用临床前模型和临床方法的机制。此外，在脂质组学方面的服务扩展 稳定的同位素示踪研究将增强小动物代谢表型的能力。这个核心 已经开发出广泛的仪器，能够对广泛的小分子进行定量， 对复杂混合物中的脂类进行非靶向分析，对将肥胖与 疾病以及研究葡萄糖和脂肪酸新陈代谢的方法。这些分析功能中的每一个 与关注饮食、营养和肥胖在疾病发展中的研究直接相关。这个核心有 自2008年以来在高影响力期刊上发表的110多篇同行评议论文的投稿数据，提供 为60多名研究人员提供了服务，并为环境科学的新赠款做出了贡献。这个 核心设备齐全，随着服务的扩大，预计将在阶段发展自给自足的能力 《公约》第三章。