Core B - Analytical Core

核心 B - 分析核心

• 批准号: 10225371
• 负责人: ANDREW J MORRIS
• 金额: $ 19.13万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10225371
• 关键词: Adipose tissue; Analytical Chemistry; Animals; Area; Award; Biological Assay; Biological Markers; Blood; Cardiovascular Diseases; Centers of Research Excellence; Clinical; Collaborations; Complex Mixtures; Core Facility; Coupled; Data; Development; Diet; Diet and Nutrition; Dietary Carbohydrates; Dietary Fats; Disease; Ecology; Ensure; Fees; Funding; Glucose; Goals; Grant; High Pressure Liquid Chromatography; Human; Incidence; Individual; Institution; Journals; Kentucky; Laboratories; Link; Lipids; Malignant Neoplasms; Mass Fragmentography; Mass Spectrum Analysis; Measures; Medicine; Methods; National Institute of Environmental Health Sciences; Neurodegenerative Disorders; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Obesity associated disease; Peer Review; Phase; Phospholipids; Pre-Clinical Model; Publications; Reporting; Research; Research Personnel; Research Support; Resolution; Resources; Risk Factors; Rural; Services; Structure; Testing; Time; Tissues; Tracer; Training and Education; Triglycerides; United States National Institutes of Health; Urine; analytical method; base; biomarker development; cardiovascular risk factor; cohort; college; computational platform; disorder risk; energy balance; fatty acid metabolism; human disease; human subject; instrumentation; interest; lipid metabolism; lipidomics; metabolic abnormality assessment; metabolic phenotype; obesity development; operation; programs; small molecule; stable isotope; western diet

The Phase III Analytical Core will support research into mechanisms linking obesity, lipid metabolism and human disease risk through continued use of facility core instrumentation and resources to develop and support a suite of analytical services tailored for studies of the relationship between diet, obesity and disease mechanisms using preclinical models and clinical approaches. In addition, expansion of services in lipidomics and stable isotope tracer studies will augment capabilities for small animal metabolic phenotyping. This core has developed extensive instrumentation that enables quantitation of a broad range of small molecules, untargeted profiling of lipids in complex mixtures, targeted quantification of biomarkers linking obesity to disease, and methods for studies of glucose and fatty acid metabolism. Each of these analytical capabilities are of direct relevance to studies focused on diet, nutrition, and obesity in disease development. This core has contributed data for more than 110 peer reviewed publications since 2008 in high impact journals, provided services for more than 60 investigators, and contributed to new grant awards in environmental sciences. The core is well equipped, and with expanded services is anticipated to develop self-sustaining capacity in Phase III of the COCVD.

III期分析核心将支持对肥胖、脂质代谢和肥胖之间联系机制的研究。 通过继续使用设施核心仪器和资源， 支持一套为研究饮食、肥胖和疾病之间关系而量身定制的分析服务 使用临床前模型和临床方法的机制。此外，扩大脂质组学服务 稳定同位素示踪研究将增强小动物代谢表型分析的能力。这一核心 已经开发了广泛的仪器，能够定量范围广泛的小分子， 复杂混合物中脂质的非靶向分析，将肥胖与 疾病以及研究葡萄糖和脂肪酸代谢的方法。每一种分析能力 与关注饮食、营养和肥胖在疾病发展中的作用的研究直接相关。这个核心有 自2008年以来，在高影响力期刊上为110多篇同行评审的出版物提供了数据， 为60多名调查人员提供服务，并为环境科学的新赠款做出了贡献。的 核心部队装备精良，随着服务的扩大，预计将在第三阶段发展自我维持能力。 第三，COCVD。