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Symposium on Cancer Metastasis and Lymphovascular System

癌症转移与淋巴血管系统研讨会

基本信息

批准号：
6838018
负责人：
STANLEY P L LEONG
金额：
$ 0.3万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-01 至 2005-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6838018
关键词：
lymph node neoplasm lymphatic circulation meeting /conference /symposium metastasis neoplasm /cancer diagnosis travel

项目摘要

DESCRIPTION (provided by applicant): In human solid cancer, the lymph node status is the most important prognostic indicator for the clinical outcome of patients. Recent developments in the sentinel lymph node (SLN) concept and technology have resulted in the application of such a revolutionary procedure to define the first draining or sentinel lymph node that the cancer will metastasize to. The critical issue to be defined is the role of the SLN in the process of lymphatic metastasis. Significant advances have been made in the study of molecular events of metastasis through the lymphovascular system. Advances in SLN technology have opened a window of opportunity to study micrometastasis in the SLN. This proposed symposium will review the basic science of cancer metastasis through the lymphovascular system and molecular mechanisms of "seed and soil" of metastasis. New paradigms of cancer growth, proliferation, overcoming apoptosis are exploited in the development of anticancer treatment. Clinical trials using molecules as inhibitors against growth factor receptors, signaling pathways and angiogenesis or those facilitating apoptosis will be reviewed. This timely symposium will bring together the basic scientists and clinicians to ask the central question of the role of the lymphovascular system in the spread of cancer and develop logical strategies to curb the process of metastasis. After participating in this symposium, physicians and research scientists should be able to: 1) Characterize the anatomy and physiology of the lymphovascular system; 2) Describe the mechanisms of metastasis; 3) Describe the prognostic factors and clinical outcome of metastasis; 4) Understand immune responses of draining lymph nodes against cancer; 5) Understand the rationale and principles of adjuvant therapy for human solid cancer; and 6) Explain the rationale of adopting molecular therapeutics against growth factor receptors, apoptotic factors, signaling pathways and angiogenesis.

描述（由申请方提供）：在人类实体癌中，淋巴结状态是患者临床结局的最重要预后指标。前哨淋巴结（SLN）概念和技术的最新发展导致了这种革命性手术的应用，以确定癌症将转移的第一个引流或前哨淋巴结。需要明确的关键问题是SLN在淋巴转移过程中的作用。通过淋巴血管系统转移的分子事件的研究已经取得了重大进展。 SLN技术的进步为研究SLN微转移提供了机会。本次研讨会将通过淋巴血管系统和转移的“种子和土壤”的分子机制来回顾癌症转移的基础科学。癌症生长、增殖、克服细胞凋亡的新范例在抗癌治疗的发展中被利用。临床试验使用的分子作为抑制剂对生长因子受体，信号通路和血管生成或那些促进细胞凋亡将进行审查。这个及时的研讨会将汇集基础科学家和临床医生，提出淋巴血管系统在癌症扩散中的作用的核心问题，并制定合理的策略来抑制转移的过程。通过参加本次研讨会，医生和研究科学家应该能够：1）描述淋巴血管系统的解剖学和生理学特征; 2）描述转移的机制; 3）描述转移的预后因素和临床结局; 4）了解引流淋巴结对癌症的免疫反应; 5）了解人类实体癌辅助治疗的原理和原则; 6）解释采用针对生长因子受体、凋亡因子、信号通路和血管生成的分子疗法的原理。