International Symposium on Cancer Metastasis and the Lymphovascular System

描述（由申请人提供）：在人类实体癌中，淋巴结状态是患者预后最重要的预后指标。前哨淋巴结（SLN）概念和技术的最新发展导致了这种方法的应用，以确定癌症将转移到的第一个引流淋巴结或SLN。在即将举行的研讨会上，将仔细讨论癌细胞的淋巴管生成和血管生成过程。癌症是最初通过淋巴系统（培养器假说）扩散，还是同时通过淋巴和血管系统（标记假说）扩散，都将被仔细研究。将检查对癌症的免疫力。将讨论干细胞作为转移的主要细胞群的作用。综述了肿瘤分子成像的研究进展，并探讨了纳米颗粒在癌症检测中的应用。分子靶向针对分子参与增殖，信号通路和凋亡将讨论。癌症的基因组特征将被探索。这次及时的研讨会将汇集来自美国和国外的基础科学家和临床医生，讨论淋巴血管系统在癌症转移中的作用这一关键问题，并制定合理的策略来遏制其扩散。参加本次研讨会后，与会者应能够：1)了解肿瘤微环境中肿瘤增殖的机制；2)描述肿瘤通过淋巴血管系统转移的机制；3)认识到干细胞在肿瘤转移中的作用；4)了解纳米颗粒在分子成像中的潜在应用；5)把握孵化器和市场假说；6) sln肿瘤负荷与临床预后的相关性；7)了解引流淋巴结对癌症的免疫反应；8)解释采用针对生长因子受体、凋亡因子、信号通路和血管生成的分子疗法的基本原理；9)了解癌症的基因组特征与临床结果的关系。

DESCRIPTION (provided by applicant): In human solid cancer, the nodal status is the most important prognostic indicator for patients' outcome. Recent developments in the sentinel lymph node (SLN) concept and technology have resulted in the application of such a procedure to define the first draining node or SLN that the cancer will metastasize to. In the upcoming symposium, the process of lymphangiogensis and hemangiogenesis by cancer cells will be carefully addressed. Whether the cancer spreads through the lymphatic system initially (incubator hypothesis) or simultaneosly through the lymphatic and vascular system (marker hypothesis) will be scrutinized. Immunity to cancer will be examined. The role of stem cells as the primary cell population to metastasize will be addressed. Advances in molecular imaging of cancer will be summarized and the use of nanoparticles for cancer detection will be explored. Molecular targeting against molecules involved in proliferation, signalling pathways and apoptosis will be discussed. Genomic signatures of cancer will be explored. This timely symposium will bring together the basic scientists and clinicians from the US and abroad to ask the critical question of the role of the lymphovascular system in cancer metastasis and develop logical strategies to curb its spread. After participating in this symposium, attendees should be able to: 1) understand the mechanisms of tumor proliferation in the tumor microenvironment; 2) describe the mechanisms of metastasis through the lymphovascular system; 3) recognize the role of stem cells in cancer metastasis; 4) appreciate the potential use of nanoparticles in molecular imaging; 5) grasp the incubator and marker hypothesis; 6) correlate the tumor burden in SLNs and clinical outcome; 7) comprehend immune responses of draining lymph nodes against cancer; 8) explain the rationale of adopting molecular therapeutics against growth factor receptors, apoptosis factors, signaling pathways and angiogenesis; and 9) learn about the genomic signatures of cancer for correlation with clinical outcome.