International Symposium on Cancer Metastasis and the Lymphovascular System

癌症转移与淋巴血管系统国际研讨会

• 批准号: 7226954
• 负责人: STANLEY P L LEONG
• 金额: $ 2.2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7226954
• 关键词: Address; Adopted; Apoptosis; Cancer Detection; Cells; Clinical; Development; Genomics; Growth Factor Receptors; Human; Immune response; Immunity; Incubators; International; Learning; Lymphatic; Lymphatic System; Lymphovascular; Malignant Lymph Node Neoplasm; Malignant Neoplasms; Molecular; Molecular Target; Neoplasm Metastasis; Nodal; Outcome; Patients; Population; Procedures; Process; Role; Scientist; Sentinel Lymph Node; Signal Pathway; Solid; Stem cells; System; Technology; Therapeutic; Tumor Burden; Vascular System; angiogenesis; cancer cell; concept; grasp; lymph nodes; molecular imaging; nanoparticle; prognostic; symposium; tumor

DESCRIPTION (provided by applicant): In human solid cancer, the nodal status is the most important prognostic indicator for patients' outcome. Recent developments in the sentinel lymph node (SLN) concept and technology have resulted in the application of such a procedure to define the first draining node or SLN that the cancer will metastasize to. In the upcoming symposium, the process of lymphangiogensis and hemangiogenesis by cancer cells will be carefully addressed. Whether the cancer spreads through the lymphatic system initially (incubator hypothesis) or simultaneosly through the lymphatic and vascular system (marker hypothesis) will be scrutinized. Immunity to cancer will be examined. The role of stem cells as the primary cell population to metastasize will be addressed. Advances in molecular imaging of cancer will be summarized and the use of nanoparticles for cancer detection will be explored. Molecular targeting against molecules involved in proliferation, signalling pathways and apoptosis will be discussed. Genomic signatures of cancer will be explored. This timely symposium will bring together the basic scientists and clinicians from the US and abroad to ask the critical question of the role of the lymphovascular system in cancer metastasis and develop logical strategies to curb its spread. After participating in this symposium, attendees should be able to: 1) understand the mechanisms of tumor proliferation in the tumor microenvironment; 2) describe the mechanisms of metastasis through the lymphovascular system; 3) recognize the role of stem cells in cancer metastasis; 4) appreciate the potential use of nanoparticles in molecular imaging; 5) grasp the incubator and marker hypothesis; 6) correlate the tumor burden in SLNs and clinical outcome; 7) comprehend immune responses of draining lymph nodes against cancer; 8) explain the rationale of adopting molecular therapeutics against growth factor receptors, apoptosis factors, signaling pathways and angiogenesis; and 9) learn about the genomic signatures of cancer for correlation with clinical outcome.

描述（由申请人提供）：在人类实体癌中，淋巴结状态是患者结局的最重要预后指标。 前哨淋巴结（SLN）概念和技术的最新发展导致了这种手术的应用，以确定癌症将转移到的第一个引流结或SLN。 在即将举行的研讨会上，将仔细讨论癌细胞的淋巴管生成和血管生成过程。癌症最初是通过淋巴系统扩散（孵化器假说）还是通过淋巴和血管系统扩散（标记假说）将被仔细检查。 将检查对癌症的免疫力。 干细胞作为转移的主要细胞群体的作用将得到解决。将总结癌症分子成像的进展，并探讨使用纳米粒子进行癌症检测。 分子靶向分子参与增殖，信号通路和凋亡将进行讨论。 将探索癌症的基因组特征。 这个及时的研讨会将汇集来自美国和国外的基础科学家和临床医生，提出淋巴血管系统在癌症转移中的作用的关键问题，并制定合理的策略来遏制其扩散。 通过参加本次研讨会，与会者应能够：1）了解肿瘤微环境中肿瘤增殖的机制; 2）描述通过淋巴血管系统转移的机制; 3）认识干细胞在癌症转移中的作用; 4）欣赏纳米颗粒在分子成像中的潜在用途; 5）掌握孵化器和标记假说; 6）将SLN中的肿瘤负荷与临床结果相关联; 7）理解引流淋巴结对癌症的免疫反应; 8）解释采用针对生长因子受体、凋亡因子、信号传导通路和血管生成的分子疗法的原理;以及9）了解癌症的基因组特征与临床结果的相关性。