International Conference-Structural Mechanisms in Muscle

国际会议-肌肉结构机制

• 批准号: 6812869
• 负责人: Avril V. Somlyo
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-16 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6812869
• 关键词: meeting /conference /symposium; muscle function; muscle proteins; protein structure function

DESCRIPTION (provided by applicant): The goal of this two-day international conference to be held on May 20th and 21st 2004 in New Hunt's House, King's College London is to highlight recent advances in the structure and function of proteins in muscle. Muscle is the most abundant tissue in the human body and its proper function is essential in many aspects of health. Deterioration of muscle function is a prominent symptom in ageing, heart disease, atherosclerosis and such devastating genetic diseases such as muscular dystrophy. Much of our current understanding of muscle and of contractile and regulatory mechanisms of muscle stems from the sliding filament hypothesis that was formulated fifty years ago. One of the four co-authors in the two Nature papers that marked the formulation was Dr Jean Hanson. She went on to become Director of the Randall Institute (now the Randall Centre, sited in New Hunt's House). This conference celebrates her scientific contributions and the research that has followed from her work. It focuses in particular on the filamentous proteins, actin and myosin, and their associated proteins to which she made such notable and seminal contributions during her career before her premature death in 1973. A principal aim therefore of the conference is to attract and enhance the interest and commitment of young, and especially women, scientists to muscle research. The meeting will be a combination of talks by internationally recognized scientists and young scientists, and of poster presentations. Scientific themes will concentrate on structural mechanisms involving proteins of the thick and thin filaments in muscle. A remarkable outgrowth of research in muscle is the way in which techniques developed to investigate its structure, mechanisms and development have pervaded so much of biological studies involving extra and intracellular movement. Approaches include single-molecule nanotechnology, synchrotron radiation and the genetic basis of disease, all of which will be exemplified in the topics discussed at the conference.

描述（由申请人提供）： 这次为期两天的国际会议将于 2004 年 5 月 20 日至 21 日在伦敦国王学院 New Hunt's House 举行，其目的是强调肌肉蛋白质结构和功能方面的最新进展。肌肉是人体中最丰富的组织，其正常功能对于健康的许多方面至关重要。肌肉功能恶化是衰老、心脏病、动脉粥样硬化和肌营养不良等破坏性遗传疾病的一个突出症状。 我们目前对肌肉以及肌肉收缩和调节机制的理解大部分源于五十年前提出的滑动丝假说。 Jean Hanson 博士是《自然》杂志上发表的两篇标志着该配方的论文的四位合著者之一。她后来成为兰德尔研究所（现为兰德尔中心，位于新亨特之家）的主任。这次会议庆祝她的科学贡献和她的工作所进行的研究。会议特别关注丝状蛋白、肌动蛋白和肌球蛋白及其相关蛋白，她在 1973 年英年早逝之前的职业生涯中对这些蛋白做出了显着的开创性贡献。因此，会议的主要目的是吸引和增强年轻科学家，特别是女性科学家对肌肉研究的兴趣和承诺。会议将结合国际知名科学家和年轻科学家的演讲以及海报展示。科学主题将集中于涉及肌肉粗丝和细丝蛋白质的结构机制。 肌肉研究的一个显着成果是，为研究其结构、机制和发育而开发的技术已经渗透到许多涉及细胞外和细胞内运动的生物学研究中。方法包括单分子纳米技术、同步辐射和疾病的遗传基础，所有这些都将在会议讨论的主题中进行举例说明。