International Conference-Structural Mechanisms in Muscle

国际会议-肌肉结构机制

• 批准号: 6812869
• 负责人: Avril V. Somlyo
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-16 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6812869
• 关键词: meeting /conference /symposium; muscle function; muscle proteins; protein structure function

DESCRIPTION (provided by applicant): The goal of this two-day international conference to be held on May 20th and 21st 2004 in New Hunt's House, King's College London is to highlight recent advances in the structure and function of proteins in muscle. Muscle is the most abundant tissue in the human body and its proper function is essential in many aspects of health. Deterioration of muscle function is a prominent symptom in ageing, heart disease, atherosclerosis and such devastating genetic diseases such as muscular dystrophy. Much of our current understanding of muscle and of contractile and regulatory mechanisms of muscle stems from the sliding filament hypothesis that was formulated fifty years ago. One of the four co-authors in the two Nature papers that marked the formulation was Dr Jean Hanson. She went on to become Director of the Randall Institute (now the Randall Centre, sited in New Hunt's House). This conference celebrates her scientific contributions and the research that has followed from her work. It focuses in particular on the filamentous proteins, actin and myosin, and their associated proteins to which she made such notable and seminal contributions during her career before her premature death in 1973. A principal aim therefore of the conference is to attract and enhance the interest and commitment of young, and especially women, scientists to muscle research. The meeting will be a combination of talks by internationally recognized scientists and young scientists, and of poster presentations. Scientific themes will concentrate on structural mechanisms involving proteins of the thick and thin filaments in muscle. A remarkable outgrowth of research in muscle is the way in which techniques developed to investigate its structure, mechanisms and development have pervaded so much of biological studies involving extra and intracellular movement. Approaches include single-molecule nanotechnology, synchrotron radiation and the genetic basis of disease, all of which will be exemplified in the topics discussed at the conference.

描述（由申请人提供）： 这项为期两天的国际会议将于2004年5月20日和21日在伦敦国王学院的新亨特家举行的为期两天的国际会议的目标是强调蛋白质在肌肉中的结构和功能的最新进展。肌肉是人体中最丰富的组织，其适当的功能在健康的许多方面至关重要。肌肉功能的恶化是衰老，心脏病，动脉粥样硬化以及诸如肌肉营养不良等毁灭性遗传疾病的重要症状。 我们目前对肌肉和收缩和肌肉的调节机制的理解大部分源于五十年前提出的滑动丝假说。标志着配方的两篇自然论文中的四位合着者之一是让·汉森博士。她继续担任兰德尔研究所（Randall Institute）的董事（现在是兰德尔中心（Randall Center），位于新亨特（New Hunt）的家中）。这次会议庆祝了她的科学贡献以及她的工作随之而来的研究。它特别关注丝状蛋白质，肌动蛋白和肌球蛋白及其相关的蛋白质，在1973年过早死亡之前，她在职业生涯中做出了如此明显和精确的贡献。因此，这次会议的主要目的是吸引和增强年轻人的兴趣和承诺，尤其是妇女，妇女，科学家，科学家，肌肉研究。这次会议将是国际认可的科学家和年轻科学家以及海报演讲的会谈。科学主题将集中于涉及肌肉厚和薄细丝的蛋白质的结构机制。 肌肉研究的显着产物是研究其结构，机制和发展的技术的发展方式，遍布许多涉及额外和细胞内运动的生物学研究。方法包括单分子纳米技术，同步加速器辐射和疾病的遗传基础，所有这些都将在会议上讨论的主题中举例说明。