Frontiers in Structural Biology

结构生物学前沿

• 批准号: 6748016
• 负责人: MICHAEL FINLEY SUMMERS
• 金额: $ 0.3万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6748016
• 关键词: X ray crystallography; meeting /conference /symposium; nuclear magnetic resonance spectroscopy; structural biology; travel

DESCRIPTION (provided by applicant): Structural biologists are deciphering the mechanisms of complex biological processes at a breathtaking pace. X-ray crystallography is providing atomic-resolution structures of complex molecular assemblies, and NMR spectroscopy is providing structural and dynamical information for ever-larger biomolecules in solution and in membranes. Fluorescence spectroscopy is yielding images of macromolecular machines at work both in vitro and in vivo. This wealth of structural information is complemented by dramatic improvements in the computational analysis of the structure and dynamics of biological macromolecules. The integration of all this new information requires an inter-disciplinary approach that utilizes a wide range of biochemical and biophysical tools to probe molecular function, while keeping the biologically important questions at center stage. The Keystone Meeting will bring together structural biologists interested in these issues, which have important implications both for fundamental biology and for the process of drug discovery.

结构生物学家正在以惊人的速度破译复杂生物过程的机制。 X射线晶体学提供了复杂分子组装的原子分辨率结构，NMR光谱学提供了溶液和膜中越来越大的生物分子的结构和动力学信息。 荧光光谱学正在产生体外和体内工作的大分子机器的图像。 生物大分子结构和动力学的计算分析得到了巨大的改进，从而补充了丰富的结构信息。 所有这些新信息的整合需要一种跨学科的方法，利用广泛的生物化学和生物物理工具来探测分子功能，同时保持生物学上的重要问题处于中心地位。 Keystone会议将汇集对这些问题感兴趣的结构生物学家，这些问题对基础生物学和药物发现过程都具有重要意义。