Research Conference:Mutagenesis and Carcinogenesis

据估计，所有人类癌症的60-90%是由外源性物质引起的，主要是人类在食物、水和空气中接触到的化学物质，癌症（以及其他疾病）通常是由诱变事件引起的，可由多种机制引起，包括由内源性或外源性物质（化学物质）形成的细胞加工和DNA损伤（或加合物）。本提案描述了第二次（2002年3月3日至8日，加利福尼亚州文图拉）和（2004年）关于诱变和致癌（M&C）的戈登研究会议（GRC）。这些会议将汇集DNA加合物诱变各方面的专家。会议将讨论三个基本领域。致突变机制，包括加合物结构和构象，加合物诱变和损伤绕过DNA聚合酶。突变避免机制，包括加合物DNA修复、细胞周期阻滞和细胞凋亡。[3]突变与癌变的关系。广泛的主题将吸引不同的科学家群体，他们对细胞诱变机制、突变避免机制以及诱变与致癌之间的关系有共同的兴趣。该领域的顶尖科学家将介绍和评估突变和致癌前沿的最新研究。

It has been estimated that 60-90% of all human cancers are caused by exogenous agents, principally chemicals that humans are exposed to in food, water and air, Cancer (as well as other diseases) are usually by mutagenic events, which can be induced by a variety of mechanisms, including by cellular processing and DNA lesions (or adducts) formed from either endogenous or exogenous agents (chemicals). This proposal describes the second (Ventura, CA, March 3 - 8, 2002) and (2004) Gorden Research Conferences (GRC) on Mutagenesis and Carcinogenesis (M&C). These conferences will bring together experts in various aspects of DNA adduct-induced mutagenesis. Sessions will address three fundamental areas. [1] Mutagenic mechanisms, including adduct structure and conformation, adduct mutagenesis, and lesion bypass DNA polymerases. [2] Mutagenesis avoidance mechanisms, including adduct DNA repair, cell cycle arrest and apoptosis. [3] The relationship between mutagenesis and carcinogenesis. The breadth of topics will attract a diverse group of scientists with common interests in cellular mutagenic mechanisms, mutation avoidance mechanisms and the relationship between mutagenesis and carcinogenesis. Leading scientists in the field will present and evaluate the latest research at the frontiers of mutagenesis and carcinogenesis.