Imaging Tumor Expression of Cyclooxygenase-2

Cyclooxygenase-2 的肿瘤表达成像

• 批准号: 7490266
• 负责人: LAWRENCE J. MARNETT
• 金额: $ 11.36万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-22 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7490266
• 关键词: Biological Availability; Cells; Clinical; Coxibs; Development; Drug Kinetics; Enzymes; Epidermal Growth Factor Receptor; Epithelial; Human; Image; Label; Laboratories; Metabolism; Modality; Molecular Target; Monitor; Optics; Positron-Emission Tomography; Property; Prostaglandin-Endoperoxide Synthase; Protocols documentation; Research; Series; Solid Neoplasm; Testing; Tissues; Xenograft Model; base; concept; cyclooxygenase 1; cyclooxygenase 2; design; in vivo; innovation; malignant breast neoplasm; molecular imaging; mouse model; optical imaging; pre-clinical; programs; response; single photon emission computed tomography; tumor; tumor growth; tumor xenograft

Project 2 proposes to develop fluorescent, PET, and SPECT imaging agents targeted to the enzyme, cyclooxygenase (COX)-2. COX-2 is highly expressed in many solid tumors but not in most untransformed epithelial tissues. Thus, it makes an attractive target for molecular imaging. All of the reviewers of this project agreed that there is a strong rationale for targeting COX-2. They also felt that the research was innovative because, although other laboratories have attempted to develop COX-targeted imaging agents, none have succeeded. Despite the high enthusiasm for the concept, the reviewers were critical of certain aspects of the proposed research plan.

项目2提出开发针对环氧合酶的荧光、PET和SPECT显像剂 （考克斯）-2。考克斯-2在许多实体瘤中高度表达，但在大多数未转化的肿瘤中不表达 上皮组织因此，它成为分子成像的有吸引力的目标。这个项目的所有评审员 同意靶向考克斯-2有很强的理由。他们还认为这项研究是创新的，因为， 尽管其它实验室已尝试开发COX靶向显像剂，但没有一个成功。 尽管对这一概念的热情很高，但审查人员对拟议的 研究计划。